Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24034
Abstract: Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of… read more here.
Keywords: rab7 may; disease; neurologic diseases; therapeutic target ... See more keywords
Structural mechanism for regulation of Rab7 by site-specific monoubiquitination.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.11.074
Abstract: Site-specific ubiquitination can regulate the functions of Rab proteins in membrane trafficking. Previously we showed that site-specific monoubiquitination on Rab5 downregulates its function. Rab7 acts in the downstream of Rab5. Although site-specific ubiquitination of Rab7… read more here.
Keywords: site specific; site; specific monoubiquitination; ubiquitination ... See more keywords
Rab7 empowers renal tubular epithelial cells with autophagy‐mediated protection against albumin‐induced injury
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.06.019
Abstract: &NA; Most patients with chronic kidney disease (CKD) present with proteinuria and extracellular matrix (ECM) deposition in the interstitium. Matrix metalloproteinase‐2 (MMP‐2) is important for maintaining ECM metabolism and it affects the formation and development… read more here.
Keywords: mmp; albumin induced; renal tubular; albumin ... See more keywords
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0166-8
Abstract: Increasing evidence suggests that Ras-related in brain 7 (Rab7), an endosome-localized small GTPase contributes to cerebral ischemic brain injury. In the present study, we investigated the role of Rab7 in ischemic stroke-induced formation of astrogliosis… read more here.
Keywords: ischemic stroke; brain atrophy; neurologic deficits; rab7 ... See more keywords
NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1760623
Abstract: ABSTRACT NRBF2 is a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex. Our previous study has revealed its role in regulating ATG14-associated PtdIns3K activity for autophagosome initiation. In this study, we revealed an unknown… read more here.
Keywords: protein; autophagosome maturation; degradation; ccz1 ... See more keywords
FYCO1 mediates clearance of α‐synuclein aggregates through a Rab7‐dependent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14461
Abstract: Parkinson's disease can be caused by mutations in the α‐synuclein gene and is characterized by aggregates of α‐synuclein protein. We have previously shown that over‐expression of the small GTPase Rab7 can induce clearance of α‐synuclein… read more here.
Keywords: synuclein; synuclein aggregates; fyco1; clearance ... See more keywords
Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.199729
Abstract: ABSTRACT Retromer is a multimeric protein complex that mediates endosome-to-trans-Golgi network (TGN) and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's disease and Parkinson's disease. The recruitment… read more here.
Keywords: endosome tgn; palmitoylation; tgn trafficking; efficient endosome ... See more keywords
A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.247080
Abstract: ABSTRACT Endosome biogenesis in eukaryotic cells is critical for nutrient uptake and plasma membrane integrity. Early endosomes initially contain Rab5, which is replaced by Rab7 on late endosomes prior to their fusion with lysosomes. Recruitment… read more here.
Keywords: gef complex; gef; mon1 ccz1; bulli ... See more keywords
The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.260395
Abstract: ABSTRACT Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex initiates mitophagosome formation remains unknown. The Rab7 GTPase (herein referring… read more here.
Keywords: ser phosphorylation; rab7; ulk complex; mitophagy ... See more keywords
Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Aging"
DOI: 10.18632/aging.203648
Abstract: Renal hypoxia is associated with persisting peritubular capillary rarefaction in progression of chronic kidney disease (CKD), and this phenomenon mainly resulted from the dysregulated angiogenesis. Rab7 is known to be involved in renal hypoxia. However,… read more here.
Keywords: knockdown rab7; angiogenesis; renal hypoxia; hypoxia ... See more keywords
This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00129
Abstract: Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission. Like all Rab GTPases, Rab7 cycles between an… read more here.
Keywords: rab7 nucleotide; nucleotide binding; endolysosomal trafficking; trafficking autophagy ... See more keywords