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   Articles with "rab7a" as a keyword



SIRT5‐Mediated Desuccinylation of RAB7A Protects Against Cadmium‐Induced Alzheimer's Disease‐Like Pathology by Restoring Autophagic Flux

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202402030

Abstract: Cadmium (Cd) is a neurotoxic contaminant that induces cognitive decline similar to that observed in Alzheimer's disease (AD). Autophagic flux dysfunction is attributed to the pathogenesis of AD, and this study aimed to investigate the… read more here.

Keywords: rab7a; alzheimer disease; autophagic flux; pathology ... See more keywords

Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2301725120

Abstract: Understanding of the evolution of metazoans from their unicellular ancestors is a fundamental question in biology. In contrast to fungi which utilize the Mon1-Ccz1 dimeric complex to activate the small GTPase RAB7A, metazoans rely on… read more here.

Keywords: rab7a; ccz1 rmc1; mon1 ccz1;

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

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recommendations! Published in 2018 at "Science Advances"

DOI: 10.1126/sciadv.aav0443

Abstract: TBK1 phosphorylates RAB7A-S72 to support multiple downstream steps in PARKIN-dependent mitophagy. Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on… read more here.

Keywords: rab7a phosphorylation; damaged mitochondria; rab7a; tbk1 ... See more keywords

Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke

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recommendations! Published in 2025 at "Acta Neuropathologica Communications"

DOI: 10.1186/s40478-025-02125-6

Abstract: The integrity of adherens and tight junctions is critical for blood-brain barrier (BBB) function in the healthy brain. Disassembly of cell junctions due to degradation of adherens and tight junction-associated proteins leads to acute BBB… read more here.

Keywords: rab7a; brain; ischemic stroke; select ... See more keywords