Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2301725120
Abstract: Understanding of the evolution of metazoans from their unicellular ancestors is a fundamental question in biology. In contrast to fungi which utilize the Mon1-Ccz1 dimeric complex to activate the small GTPase RAB7A, metazoans rely on… read more here.
Keywords: rab7a; ccz1 rmc1; mon1 ccz1;
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aav0443
Abstract: TBK1 phosphorylates RAB7A-S72 to support multiple downstream steps in PARKIN-dependent mitophagy. Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on… read more here.
Keywords: rab7a phosphorylation; damaged mitochondria; rab7a; tbk1 ... See more keywords