RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
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DOI: 10.1126/sciadv.aav0443
Abstract: TBK1 phosphorylates RAB7A-S72 to support multiple downstream steps in PARKIN-dependent mitophagy. Removal of damaged mitochondria is orchestrated by a pathway involving the PINK1 kinase and the PARKIN ubiquitin ligase. Ubiquitin chains assembled by PARKIN on… read more here.
Keywords: rab7a phosphorylation; damaged mitochondria; rab7a; tbk1 ... See more keywords