Rab9 mediates pancreatic autophagy switch from canonical to noncanonical, aggravating experimental pancreatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"
DOI: 10.1016/j.jcmgh.2021.09.017
Abstract: BACKGROUND Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonical autophagy is… read more here.
Keywords: pancreatitis; pancreatic autophagy; rab9; autophagy ... See more keywords
The overexpression of Rab9 promotes tumor progression regulated by XBP1 in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s183748
Abstract: Background Rab9 is a small GTPase that localizes to the trans-Golgi Network (TGN) and late endosomes and is involved in the recycling of mannose-6-phosphate receptors (MPRs). Materials and methods To determine new treatment strategies for… read more here.
Keywords: overexpression; cancer; breast cancer; rab9 ... See more keywords
Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models
Sign Up to like & getrecommendations! Published in 2024 at "Theranostics"
DOI: 10.7150/thno.88718
Abstract: Rationale: Promotion of mitophagy is considered a promising strategy for the treatment of neurodegenerative diseases including Alzheimer's disease (AD). The development of mitophagy-specific inducers with low toxicity and defined molecular mechanisms is essential for the… read more here.
Keywords: alternative mitophagy; mitochondrial dysfunction; mitophagy; alt001 ... See more keywords