Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system
Sign Up to like & getrecommendations! Published in 2019 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-019-1013-8
Abstract: ObjectiveTo generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.MethodsCRISPR/Cas9 system directed by a multiple sgRNAs system was used in… read more here.
Keywords: system; ldlr apoe; rabbit models; multiple sgrnas ... See more keywords
Pathological Investigations of Intracranial Atherosclerosis Using Multiple Hypercholesterolemic Rabbit Models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.834207
Abstract: Background Intracranial atherosclerosis (ICAS) is one of the most common causes of ischemic stroke, but there are few animal models that can recapitulate its pathological features. In this study, we examined ICAS pathological features and… read more here.
Keywords: hypertension; rabbit models; atherosclerosis; intracranial atherosclerosis ... See more keywords
Gene Editing in Rabbits: Unique Opportunities for Translational Biomedical Research
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.642444
Abstract: The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout… read more here.
Keywords: biomedical research; research; gene editing; unique opportunities ... See more keywords
Characterization of differentially expressed and lipid metabolism-related lncRNA-mRNA interaction networks during the growth of liver tissue through rabbit models
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.998796
Abstract: Background Characterization the long non-coding RNAs (lncRNAs) and their regulated mRNAs involved in lipid metabolism during liver growth and development is of great value for discovering new genomic biomarkers and therapeutic targets for fatty liver… read more here.
Keywords: interaction; metabolism; growth; lipid metabolism ... See more keywords
Hyperlipidemic Rabbit Models for Anti-Atherosclerotic Drug Development
Sign Up to like & getrecommendations! Published in 2020 at "Applied Sciences"
DOI: 10.3390/app10238681
Abstract: Hyperlipidemia or dyslipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are… read more here.
Keywords: drug development; rabbit models; hyperlipidemic rabbits; development ... See more keywords