Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2018.06.003
Abstract: A simple method was established for the determination of β-propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30 m × 0.32 mm i.d., 0.25 µm) capillary column at… read more here.
Keywords: human inactivated; determination; rabies vaccine; method ... See more keywords
An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.12.031
Abstract: BACKGROUND Rabies is a fatal disease where post-exposure prophylaxis (PEP) is crucial in preventing infection. However, deaths even after appropriate PEP, have been reported. The PIKA Rabies vaccine adjuvant is a TLR3 agonist that activates… read more here.
Keywords: tlr3 agonist; pika rabies; response; rabies vaccine ... See more keywords
Could the RTS,S/AS01 meningitis safety signal really be a protective effect of rabies vaccine?
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2016.12.067
Abstract: The RTS,S/AS01 malaria vaccine has been associated with meningitis and cerebral malaria safety signals. Key characteristics of the meningitis signal include presence, in the 5-17month but not the 6-12week age group, of delayed and variable… read more here.
Keywords: rts as01; protective effect; safety; effect ... See more keywords
Rabies vaccine is associated with decreased all-cause mortality in dogs.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.05.095
Abstract: Evidence suggests that rabies vaccine may have non-specific protective effects in animals and children. We analyzed four years of data (2012-2015) from an observational study of the health and demographics of a population of owned,… read more here.
Keywords: cause mortality; non specific; mortality dogs; mortality ... See more keywords
RNA-based adjuvant CV8102 enhances the immunogenicity of a licensed rabies vaccine in a first-in-human trial.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.02.024
Abstract: BACKGROUND We report the first-in-concept human trial of the safety, tolerability and immunogenicity when a novel TLR 7/8/RIG I agonist RNA-based adjuvant, CV8102, was administered alone or mixed with fractional doses of a licensed rabies… read more here.
Keywords: cv8102; based adjuvant; immunogenicity; rna based ... See more keywords
Rabies vaccine and immunoglobulin supply and logistics: Challenges and opportunities for rabies elimination in Kenya.
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DOI: 10.1016/j.vaccine.2019.05.035
Abstract: Prompt provision of post-exposure-prophylaxis (PEP) including vaccines and rabies immunoglobulin (RIG) to persons bitten by suspect rabid dogs is a key strategy to eliminating human deaths from dog-mediated rabies in Kenya by 2030. We assessed… read more here.
Keywords: supply; supply logistics; rabies vaccine; pep ... See more keywords
Safety of purified Vero cell rabies vaccine manufactured in Pakistan: a comparative analysis of intradermal and intramuscular routes
Sign Up to like & getrecommendations! Published in 2023 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2023.2197826
Abstract: Abstract Background Rabies vaccines are conventionally given via the intramuscular (IM) route; however, switching the route of administration from IM to intradermal (ID) without affecting efficacy can be advantageous in terms of cost, dosing, and… read more here.
Keywords: safety; purified vero; vero cell; cell rabies ... See more keywords
Evaluation and Correlation of Rabies Vaccine Potency Using the National Institute of Health, Rapid Focus Fluorescent Inhibition, and Passive Hemagglutination Tests.
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DOI: 10.1089/vim.2021.0181
Abstract: Rabies vaccine preparations are quantitatively assayed for potency using the in-vivo challenge National Institute of Health (NIH), the main test that consumes a high number of animals, takes a long time, and has wide variability.… read more here.
Keywords: rffit; potency; test; rffit pha ... See more keywords
A New Antibody Binding Test for Potency Assessment of the Human Rabies Vaccine.
Sign Up to like & getrecommendations! Published in 2023 at "Viral immunology"
DOI: 10.1089/vim.2022.0161
Abstract: This study established a new protocol of the antibody binding test to evaluate the potency of the rabies vaccine containing the final bulk and the product. The principle of this experiment is to combine rabies… read more here.
Keywords: rabies vaccine; binding test; potency; antibody binding ... See more keywords
Non-specific effects of rabies vaccine on the incidence of common infectious disease episodes: study protocol for a randomized controlled trial
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DOI: 10.1186/s13063-020-04467-z
Abstract: Background Vaccines may cause non-specific effects (NSEs) on morbidity and mortality through immune-mediated mechanisms that are not explained by the prevention of the targeted disease. Much of the evidence for NSEs comes from observational studies… read more here.
Keywords: trial; non specific; disease; study ... See more keywords
A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus)
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010699
Abstract: Vampire bat transmitted rabies (VBR) is a continuing burden to public health and agricultural sectors in Latin America, despite decades-long efforts to control the disease by culling bat populations. Culling has been shown to disperse… read more here.
Keywords: vampire; vaccination; bats desmodus; rcn mog ... See more keywords