Biophysical virus particle specific characterization to sharpen the definition of virus stability
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.08.006
Abstract: Graphical abstract Figure. No Caption available. Abstract Vaccine thermostability is key to successful global immunization programs as it may have a significant impact on the continuous cold‐chain maintenance logistics, as well as affect vaccine potency.… read more here.
Keywords: virus particle; virus; rabv; characterization ... See more keywords
Raccoon rabies control and elimination in the northeastern USA and southern Québec, Canada
Sign Up to like & getrecommendations! Published in 2023 at "Epidemiology and Infection"
DOI: 10.1017/s095026882300047x
Abstract: Abstract Rabies virus (RABV) is a deadly zoonosis that circulates in wild carnivore populations in North America. Intensive management within the USA and Canada has been conducted to control the spread of the raccoon (Procyon… read more here.
Keywords: occupancy; raccoon; rabv; canada ... See more keywords
Dual Role of Toll-Like Receptor 7 in the Pathogenesis of Rabies Virus in a Mouse Model
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00111-20
Abstract: Developing targeted treatment for RABV requires understanding the innate immune response to the virus because early virus clearance is essential for preventing the fatality when the infection has progressed to the CNS. Previous studies have… read more here.
Keywords: immune response; immunopathology; tlr7; receptor ... See more keywords
Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00321-20
Abstract: Rabies PEP depends on anti-RABV IgG, which is expensive and in limited supply in geographical areas with the highest disease burden. Replacing the IgG component with a cost-effective and shelf-stable small-molecule antiviral could address this… read more here.
Keywords: entry; characterization; small molecule; anti rabv ... See more keywords
Virus-Like Vesicles Based on Semliki Forest Virus-Containing Rabies Virus Glycoprotein Make a Safe and Efficacious Rabies Vaccine Candidate in a Mouse Model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00790-21
Abstract: VLVs have been shown to represent a more versatile and superior vaccine platform. In previous studies, VLVs containing the Semliki Forest virus replicase (SFV nsP1 to nsP4) and rabies virus glycoprotein (RABV-G) grew to relatively… read more here.
Keywords: semliki forest; rabies virus; virus glycoprotein; virus ... See more keywords
Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01612-22
Abstract: For most viruses, cell entry involves engagement with many distinct plasma membrane components, each of which is essential. After binding to its specific receptor(s), rabies virus (RABV) enters host cells through the process of clathrin-mediated… read more here.
Keywords: entry; tfr1; rabv; rabies virus ... See more keywords
Neuroglia infection by rabies virus after anterograde virus spread in peripheral neurons
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01074-6
Abstract: The highly neurotropic rabies virus (RABV) enters peripheral neurons at axon termini and requires long distance axonal transport and trans-synaptic spread between neurons for the infection of the central nervous system (CNS). Recent 3D imaging… read more here.
Keywords: rabies virus; field; infection; peripheral neurons ... See more keywords
Incorporating B cell activating factor (BAFF) into the membrane of rabies virus (RABV) particles improves the speed and magnitude of vaccine-induced antibody responses
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007800
Abstract: B cell activating factor (BAFF) is a member of the tumor necrosis factor (TNF) superfamily of cytokines that links innate with adaptive immunity. BAFF signals through receptors on B cells, making it an attractive molecule… read more here.
Keywords: vaccine; baff; rabv; rabv ed51 ... See more keywords
Phosphoprotein Gene of Wild-Type Rabies Virus Plays a Role in Limiting Viral Pathogenicity and Lowering the Enhancement of BBB Permeability
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00109
Abstract: Enhancement of blood–brain barrier (BBB) permeability is necessary for clearing virus in the central nervous system (CNS). It has been reported that only laboratory-attenuated rabies virus (RABV) induces inflammatory response to lead BBB transient breakdown… read more here.
Keywords: bbb; bbb permeability; role; rabv ... See more keywords
In Vivo Efficacy of a Cocktail of Human Monoclonal Antibodies (CL184) Against Diverse North American Bat Rabies Virus Variants
Sign Up to like & getrecommendations! Published in 2017 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed2030048
Abstract: Following rabies virus (RABV) exposure, a combination of thorough wound washing, multiple-dose vaccine administration and the local infiltration of rabies immune globulin (RIG) are essential components of modern post-exposure prophylaxis (PEP). Although modern cell-culture-based rabies… read more here.
Keywords: rabies virus; rig; monoclonal antibodies; bat ... See more keywords
Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v15010088
Abstract: Rabies is caused by neurotropic rabies virus (RABV), contributing to 60,000 human deaths annually. Even though rabies leads to major public health concerns worldwide, we still do not fully understand factors determining RABV tropism and… read more here.
Keywords: cell; immune responses; infection; rabv ... See more keywords