Biochemical Assays to Detect Activation of Small GTPases Rho, Rac, and Cdc42 during Morphogenesis.
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DOI: 10.1007/978-1-0716-2035-9_5
Abstract: Wnt/Frizzled (Fz) signaling controls developmental, physiological, and pathological processes through several distinct pathways. Wnt/Fz activation of the small GTPases Rho, Rac, and Cdc42, is one key mechanism that regulates cell polarity and migration during vertebrate… read more here.
Keywords: activation small; rac cdc42; small gtpases; rho rac ... See more keywords
Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry
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DOI: 10.1021/acsomega.9b01641
Abstract: The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42 inhibitor that reduces HER2-type tumor growth and metastasis in mice by ∼90%.… read more here.
Keywords: rac cdc42; cdc42 inhibitor; mbq 167; supercritical fluid ... See more keywords
Targeting Rac and Cdc42 GTPases in Cancer.
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DOI: 10.1158/0008-5472.can-18-0619
Abstract: Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal transition, cell-cycle progression, migration/invasion, tumor growth, angiogenesis, and oncogenic transformation. With the exception of… read more here.
Keywords: rac cdc42; cdc42; targeting rac; cancer ... See more keywords
Abstract 1998: Characterization of immunoliposomes for HER2-targeted delivery of the dual Rac/Cdc42 inhibitor MBQ-167
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DOI: 10.1158/1538-7445.am2023-1998
Abstract: Breast cancer is the second leading cause of mortality among women in the US. Among the various subtypes, human epidermal growth factor receptor 2 (HER2) positive breast cancer shows a very aggressive and invasive phenotype.… read more here.
Keywords: breast cancer; cancer; mbq 167; rac cdc42 ... See more keywords
Abstract 2185: Efficacy of Rac/Cdc42 inhibitors in multiple cancer models
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DOI: 10.1158/1538-7445.sabcs18-2185
Abstract: The RhoGTPases Rac and Cdc42 are excellent therapeutic targets for inhibiting metastasis because these homologous proteins regulate numerous cellular functions that promote tumorigenesis, angiogenesis, invasion and therefore, metastasis. Also, Rac1, Cdc42, and their effector p21-activated… read more here.
Keywords: cdc42; cancer; multiple cancer; rac cdc42 ... See more keywords