Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of disease"
DOI: 10.1016/j.nbd.2020.104743
Abstract: Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In the current study, we demonstrate that treatment… read more here.
Keywords: death; motor neurons; motor; rac rho ... See more keywords
Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.12.009
Abstract: Summary The Mixed Lineage Leukemia (MLL1, KMT2A) gene is critical for development and maintenance of hematopoietic stem cells (HSCs), however, whether this protein is limiting for HSC development is unknown due to lack of physiologic… read more here.
Keywords: rac rho; stem; rho integrin; integrin signaling ... See more keywords
Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006303
Abstract: Focal adhesions are protein complexes that anchor cells to the extracellular matrix. During migration, the growth and disassembly of these structures are spatiotemporally regulated, with new adhesions forming at the leading edge of the cell… read more here.
Keywords: phosphorylation serine; adhesion; adhesion dynamics; rac rho ... See more keywords