Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13236-9
Abstract: Memory consolidation theory suggests that once memory formation has been completed, memory is maintained at a stable strength and is incapable of further enhancement. However, the current study reveals that even long after formation, contextual… read more here.
Keywords: rac1 activity; maintenance; memory; long term ... See more keywords
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26324-6
Abstract: Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than… read more here.
Keywords: activity cell; rac1 activity; gtp levels; gtp ... See more keywords
Oscillatory dynamics of Rac1 activity in Dictyostelium discoideum amoebae
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Computational Biology"
DOI: 10.1101/2024.03.28.587124
Abstract: Small GTPases of the Rho family play a central role in the regulation of cell motility by controlling the remodeling of the actin cytoskeleton. In the amoeboid cells of Dictyostelium discoideum, the active form of… read more here.
Keywords: dictyostelium discoideum; discoideum amoebae; dynamics rac1; rac1 activity ... See more keywords
Balanced Rac1 activity controls formation and maintenance of neuromuscular acetylcholine receptor clusters
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.215251
Abstract: ABSTRACT Rac1, an important Rho GTPase that regulates the actin cytoskeleton, has long been suggested to participate in acetylcholine receptor (AChR) clustering at the postsynaptic neuromuscular junction. However, how Rac1 is regulated and how it… read more here.
Keywords: maintenance; formation; rac1 activity; rac1 ... See more keywords
Complement C3 Affects Rac1 Activity in the Developing Brain
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00150
Abstract: The complement system, which is part of the innate immune response system, has been recently shown to participate in multiple key processes in the developing brain. Here we aimed to elucidate downstream signaling responses linking… read more here.
Keywords: rac1 activity; complement; developing brain; activity ... See more keywords
Hedgehog signaling is controlled by Rac1 activity
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.67702
Abstract: Rationale: The nuclear translocation of transcriptional factor Gli is indispensable for Hedgehog (Hh) signaling activation, whose deregulation causes cancer progressions; however, the mechanisms governing Gli nuclear translocation are poorly understood. Here, we report that the… read more here.
Keywords: hedgehog signaling; translocation; rac1; rac1 activity ... See more keywords