Abstract 3159: Rac1 and Cdc42 as drivers in ovarian cancer metastasis
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DOI: 10.1158/1538-7445.am2018-3159
Abstract: Five-year ovarian cancer patient survival has not improved for decades, largely due to disease recurrence. Therefore, drivers of relapse need to be identified. We first reported that Rac1 and Cdc42 GTPases are highly overexpressed in… read more here.
Keywords: cancer; rac1 cdc42; ovarian cancer; metastasis ... See more keywords
Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis
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DOI: 10.3390/ijms232416137
Abstract: Background: Thrombocytopenia has long been considered an important complication of chemotherapy and radiotherapy, which severely limits the effectiveness of cancer treatment and the overall survival of patients. However, clinical treatment options are extremely limited so… read more here.
Keywords: ruxolitinib; jnk pathway; rac1 cdc42; cdc42 jnk ... See more keywords
pPe Op inhibits HGC-27 cell proliferation, migration and invasion by upregulating miR-30b-5p and down-regulating the Rac1/Cdc42 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022193
Abstract: Gastric cancer is the fifth most frequently occurring and the fourth most lethal malignant cancer worldwide. A bioactive protein (pPe Op) from Omphalia lapidescens exhibits significant inhibitory effects on gastric cancer cells. miRNA deep sequencing… read more here.
Keywords: rac1 cdc42; proliferation migration; migration invasion; ppe ... See more keywords
KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells
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DOI: 10.7150/jca.77238
Abstract: Glioma is one of the most prevalent cancers diseases in the worldwide. Kinesin superfamily protein 4 (KIF4), a KIF member classified in Kinesin 4 has been indicated as a mediator acted in tumorigenesis of human… read more here.
Keywords: cell; kif4a; glioma; rac1 cdc42 ... See more keywords