Diallyl disulfide downregulating RhoGDI2 induces differentiation and inhibit invasion via the Rac1/Pak1/LIMK1 pathway in human leukemia HL‐60 cells
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23748
Abstract: Leukemia is a type of disease in which hematopoietic stem cells proliferate clonally at the genetic level. We discovered previously by high‐resolution mass spectrometry that diallyl disulfide (DADS), which is one of the effective ingredients… read more here.
Keywords: pak1 limk1; limk1 pathway; leukemia; rhogdi2 ... See more keywords
Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.016
Abstract: Rac1 is a small member of Rho GTPase family. One of the most important downstream effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational activation of PAK1 by Rac1 has oncogenic signaling… read more here.
Keywords: rac1 pak1; pak1; gtp; intrinsic dynamics ... See more keywords