The Rac1 splice form Rac1b favors mouse colonic mucosa regeneration and contributes to intestinal cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0389-7
Abstract: We previously have identified the ectopic expression of Rac1b, an activated and novel splice variant of Rac1, in a subset of human colorectal adenocarcinomas, as well as in inflammatory bowel diseases and in colitis mouse… read more here.
Keywords: splice; inflammation; mucosa; rac1b ... See more keywords
Antagonistic effects of RAC1 and tumor-related RAC1b on NIS expression in thyroid.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-19-0195
Abstract: Thyroid cancer (TC) is the most common endocrine malignancy. The Sodium Iodide Symporter (NIS), responsible for active transport of iodide into thyroid cells, allows the use of radioactive iodine (RAI) as the systemic treatment of… read more here.
Keywords: expression; thyroid cells; rac1b; nis expression ... See more keywords
Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102640
Abstract: Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and… read more here.
Keywords: cell; alk2; migration; pancreatic ductal ... See more keywords
Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061393
Abstract: Simple Summary Tumours are now known to develop more quickly when the tumour cell mass is located in a tissue that shows signs of chronic inflammation. Under such conditions, inflammatory cells from the surrounding tumour… read more here.
Keywords: crc cells; tumour; pro inflammatory; rac1b ... See more keywords