Enhancing cofactor recycling in the bioconversion of racemic alcohols to chiral amines with alcohol dehydrogenase and amine dehydrogenase by coupling cells and cell‐free system
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26896
Abstract: Alcohol dehydrogenase (ADH) and amine dehydrogenase (AmDH)‐catalyzed one‐pot cascade conversion of an alcohol to an amine provides a simple preparation of chiral amines. To enhance the cofactor recycling in this reaction, we report a new… read more here.
Keywords: dehydrogenase; racemic alcohols; conversion; alcohol dehydrogenase ... See more keywords
Iridium-catalysed enantioselective formal deoxygenation of racemic alcohols via asymmetric hydrogenation
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DOI: 10.1038/s41929-019-0375-7
Abstract: Asymmetric hydrogenation of alkenes is one of the most powerful tools for the preparation of optically active compounds. However, to achieve high enantioselectivity, the starting olefin in most cases needs to be isomerically pure in… read more here.
Keywords: deoxygenation racemic; formal deoxygenation; hydrogenation; racemic alcohols ... See more keywords
Conversion of racemic alcohols to optically pure amine precursors enabled by catalyst dynamic kinetic resolution: experiment and computation.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc02881a
Abstract: An unprecedented base metal catalysed asymmetric synthesis of α-chiral amine precursors from racemic alcohols is reported. This redox-neutral reaction utilises a bench-stable manganese complex and Ellman's sulfinamide as a versatile ammonia surrogate. DFT calculations explain… read more here.
Keywords: racemic alcohols; kinetic resolution; dynamic kinetic; enabled catalyst ... See more keywords