Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19F NMR Spectroscopy
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DOI: 10.1021/acsomega.2c03316
Abstract: With renewed interest in atropisomerism of drug molecules, efficient methods to experimentally determine torsion rotational energy barriers are needed. Here, we describe use of the chiral phosphoric acid solvating agent (+)-TiPSY to resolve the signals… read more here.
Keywords: spectroscopy; solvating agent; 19f nmr; kinetics mrtx1719 ... See more keywords
Multistep Chirality Transfer and Racemization Kinetics of Pillar [5]arenes by Tuning the Halogen Substituents on the Rims
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DOI: 10.1039/d4qo01799d
Abstract: Halogen-substituted pillar[5]arenes exhibited hindered hydroquinone subunit flipping, enabling enantioseparation. An enantiopure conformer demonstrated a dissymmetric factor of 0.012 and an enantioselective binding ratio exceeding 1.92. Complexation with L-serine induced an... read more here.
Keywords: chirality transfer; transfer racemization; racemization kinetics; halogen ... See more keywords