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   Articles with "rack1" as a keyword



Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1-Mediated Astrocytic Phagocytosis.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202515877

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disorder. Microglia make significant contributions to neuroinflammation and the progression of AD. However, the regulatory role of microglial activation and the communication between microglia and astrocytes in… read more here.

Keywords: rack1; alzheimer disease; microglial rack1; pathology ... See more keywords

Integrin beta and receptor for activated protein kinase C are involved in the cell entry of Bombyx mori cypovirus

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recommendations! Published in 2017 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-017-8158-z

Abstract: Receptor-mediated endocytosis using a β1 integrin-dependent internalization was considered as the primary mechanism for the initiation of mammalian reovirus infection. Bombyx mori cypovirus (BmCPV) is a member of Reoviridae family which mainly infects the midgut… read more here.

Keywords: rack1; cell entry; bmcpv; receptor ... See more keywords

Downregulation of tumor suppressor RACK1 by Helicobacter pylori infection promotes gastric carcinogenesis through the integrin β-1/NF-κB signaling pathway.

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2019.02.039

Abstract: Receptor of activated protein kinase C 1 (RACK1) is downregulated in gastric cancer and is involved in modulating NF-κB signaling pathway activity. However, the underlying molecular mechanisms regulating RACK1 expression are unclear. In this study,… read more here.

Keywords: rack1; signaling pathway; pylori infection; expression ... See more keywords
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The receptor for activated C kinase 1 (RACK1) mediating immune response in thick shell mussel Mytilus coruscus

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recommendations! Published in 2018 at "Developmental and Comparative Immunology"

DOI: 10.1016/j.dci.2018.04.004

Abstract: ABSTRACT The receptor for activated C kinase 1 (RACK1) is a intracellular receptor for the protein kinase C family which mediates various biological processes. Here, a novel RACK1 gene termed Mc‐RACK1 was identified from thick… read more here.

Keywords: activated kinase; mytilus coruscus; receptor activated; rack1 ... See more keywords

Overexpression of RACK1 enhanced the replication of porcine reproductive and respiratory syndrome virus in Marc-145 cells and promoted the NF-κB activation via upregulating the expression and phosphorylation of TRAF2.

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recommendations! Published in 2019 at "Gene"

DOI: 10.1016/j.gene.2019.05.046

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative pathogen for porcine reproductive and respiratory syndrome (PRRS), which lead to huge loss to porcine industry. RACK1 (receptor of activated protein C kinase 1) was… read more here.

Keywords: rack1; 145 cells; porcine reproductive; activation ... See more keywords

Role of RACK1 on cell proliferation, adhesion, and bortezomib-induced apoptosis in multiple myeloma.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.10.034

Abstract: Receptor for activated C kinase 1 (RACK1), a scaffold protein, plays a crucial role in the progression of various cancers. However, the biological function and underlying mechanism of RACK1 in multiple myeloma (MM) cells remain… read more here.

Keywords: myeloma; rack1; apoptosis; adhesion ... See more keywords
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RACK1 is an organ-specific prognostic predictor in OSCC.

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recommendations! Published in 2018 at "Oral oncology"

DOI: 10.1016/j.oraloncology.2017.10.025

Abstract: OBJECTIVES This study aims to verify that RACK1 is an organ-specific prognostic predictor in patients with oral squamous cell carcinoma (OSCC). EXPERIMENTAL DESIGN The RACK1 expression level was assessed by immunohistochemistry (IHC) in a total… read more here.

Keywords: specific prognostic; organ specific; rack1; predictor ... See more keywords

Arabidopsis thaliana and Oryza sativa receptor for activated C kinase 1 (RACK1) mediated signaling pathway shows hypersensitivity to oxidative stress

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recommendations! Published in 2021 at "Plant Gene"

DOI: 10.1016/j.plgene.2021.100299

Abstract: Abstract Scaffold proteins regulate cellular mechanisms and phenotypic patterns through protein-to-protein interactions. Receptor for Activated C Kinase 1 (RACK1) is a highly conserved protein containing 40 amino acid repeats of tryptophan-aspartic acid dipeptides (WD-repeat). RACK1… read more here.

Keywords: rack1; stress; thaliana; receptor activated ... See more keywords

The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity

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recommendations! Published in 2017 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2017.04.011

Abstract: ABSTRACT We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may… read more here.

Keywords: endocrine disrupting; rack1; target; scaffold protein ... See more keywords

RACK1 contributes to the upregulation of embryonic genes in a model of cardiac hypertrophy

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-76138-x

Abstract: Receptors for activated C kinases (RACKs) have been shown to coordinate PKC-mediated hypertrophic signalling in mice. However, little information is available on its participation in embryonic gene expression. This study investigated the involvement of RACK1… read more here.

Keywords: cardiac hypertrophy; rack1; heart; embryonic genes ... See more keywords

RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ.

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2421672122

Abstract: Significance Alveolar macrophage (AM) development and function depends on signature transcription factor peroxisome proliferator-activated receptor-γ (PPARγ). The regulation of PPARγ stability during AM development and maintenance remains unexplored. Here, we identify that myeloid deficiency of… read more here.

Keywords: rack1; ppar; development function; development ... See more keywords