Abstract 4839: Harnessing the cGAS-STING signaling and immune checkpoint pathways to enhance the tumor microenvironment for breast cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4839
Abstract: Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, but resistance remains common with only some patients showing lasting responses. This underscores the need to understand resistance mechanisms and develop strategies to enhance responsiveness. In… read more here.
Keywords: cancer; breast cancer; tamoxifen; immune checkpoint ... See more keywords
Investigation of a tamoxifen-RACK7/KDM5C-IFN-I axis for ER+ breast cancer immunomodulation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.23_suppl.9
Abstract: 9 Background: ER+ breast cancer patients generally have good prognosis. However, significant relapse rates (i.e., hormone drugs, Tamoxifen/TMX) and the poor response to immune checkpoint blockade (ICB) remain critical issues to be addressed. Thus, exploration… read more here.
Keywords: tmx; breast cancer; rack7; ifn ... See more keywords