Rad50 promotes ovarian cancer progression through NF-κB activation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17017
Abstract: Rad50 is a component of MRN (Mre11-Rad50-Nbs1), which participates in DNA double-strand break repair and DNA-damage checkpoint activation. Here, we sought to investigate the clinical and functional significance of Rad50 in high-grade serous ovarian cancer… read more here.
Keywords: ovarian cancer; activation; rad50 promotes; rad50 ... See more keywords
A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282277
Abstract: The MRE11A-RAD50-NBS1 complex activates the ataxia-telangiectasia mutated (ATM) pathway and plays a central role in genome homeostasis. The association of RAD50 mutations with disease remains unclear; hence, we adopted a medaka rad50 mutant to demonstrate… read more here.
Keywords: ataxia telangiectasia; medaka; rad50; rad50 medaka ... See more keywords
Overexpression of RAD50 is the Marker of Poor Prognosis and Drug Resistance in Breast Cancer Patients.
Sign Up to like & getrecommendations! Published in 2020 at "Current cancer drug targets"
DOI: 10.2174/1568009620666201009125507
Abstract: BACKGROUND The prevalence of breast cancer is increasing at an alarming rate and thus demands exploration of most relevant diagnostic biomarkers. RAD50 is a cancer susceptibility gene which encodes a DNA damage repairing protein. Its… read more here.
Keywords: cancer; rad50 expression; rad50; breast cancer ... See more keywords
RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230418101511
Abstract: BACKGROUND Breast and ovarian tumors with pathogenic variants in BRCA1 or BRCA2 genes are more sensitive to poly (ADP-ribose) polymerase inhibitors (PARPi) treatment than wild-type tumors. Pathogenic variants in non-BRCA1/2 homologous recombination repair genes (HRR)… read more here.
Keywords: breast cancer; t47d; rad50; rad50 deficient ... See more keywords
Somatic NGS Analysis of DNA Damage Response (DDR) Genes ATM, MRE11A, RAD50, NBN, and ATR in Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemo-Radiotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123247
Abstract: Background: Neoadjuvant chemo-radiotherapy (nCRT) represents the standard of care for locally advanced rectal cancer (LARC); however, there exists no biomarker that can predict the cancer’s response to treatment as less than 20% of patients experience… read more here.
Keywords: locally advanced; chemo radiotherapy; neoadjuvant chemo; rad50 ... See more keywords