A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model
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DOI: 10.1371/journal.pone.0282277
Abstract: The MRE11A-RAD50-NBS1 complex activates the ataxia-telangiectasia mutated (ATM) pathway and plays a central role in genome homeostasis. The association of RAD50 mutations with disease remains unclear; hence, we adopted a medaka rad50 mutant to demonstrate… read more here.
Keywords: ataxia telangiectasia; medaka; rad50; rad50 medaka ... See more keywords