Design of BRC analogous peptides based on the complex BRC8–RAD51 and the preliminary study on the peptide structures
Sign Up to like & getrecommendations! Published in 2020 at "Amino Acids"
DOI: 10.1007/s00726-020-02856-x
Abstract: BRCA2 is an important tumor suppressor gene that plays a critical role in preserving the stability of cellular genetic information, participating in DNA repair by engaging in binding interactions with RAD51 proteins. However, the lack… read more here.
Keywords: brc8; study; brc8 rad51; structure ... See more keywords
High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-022-06552-0
Abstract: Although the DNA repair mechanism is important in preventing carcinogenesis, its activation in established cancer cells may support their proliferation and aggravate cancer progression. RAD51 cooperates with BRCA2 and is essential in the homologous recombination… read more here.
Keywords: expression; rad51; breast cancer; gene ... See more keywords
Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress‐mediated cytotoxicity in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.09.015
Abstract: &NA; A genetic analysis of synthetic lethal interactions in yeast revealed that the mutation of SOD1, encoding an antioxidant enzyme that scavenges superoxide anion radical, impaired the growth of a set of mutants defective in… read more here.
Keywords: genomic instability; saccharomyces cerevisiae; sod1; deficiency ... See more keywords
Loss of PRDX1 increases RAD51 Cys319 oxidation and decreases homologous recombination
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.159
Abstract: Peroxiredoxin 1 (PRDX1) is an oxidative stress protein sensor, which can coordinate cell signaling of its binding partners. Loss of Prdx1 function in mice has been shown to enhance susceptibility to various cancers, including breast… read more here.
Keywords: loss prdx1; oxidation; homologous recombination; prdx1 ... See more keywords
Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Lung cancer"
DOI: 10.1016/j.lungcan.2020.06.025
Abstract: OBJECTIVES DNA repair proteins have emerged as potential predictors for immunotherapy response alongside PD-L1 expression, tumor-infiltrating lymphocytes (TILs) and tumor mutational burden. We analyzed expression of PD-L1, TILs count and expression of the homologous recombination… read more here.
Keywords: dna repair; infiltrating lymphocytes; tumor infiltrating; expression ... See more keywords
Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101604
Abstract: Ovarian cancer is the most lethal gynecological malignancy. Abnormal homologous recombination repair, high level of reactive oxygen species (ROS) and upregulation of antioxidant genes are characteristic features of ovarian cancer. However, the molecular mechanisms governing… read more here.
Keywords: depletion; dna damage; ovarian cancer; rad51 ... See more keywords
Expression of Rad51 and the histo-morphological evaluation of testis of the sterile male cattle-yak.
Sign Up to like & getrecommendations! Published in 2021 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2021.06.018
Abstract: Meiotic recombination is key to the repair of DNA double-strand break damage, provide a link between homologs for proper chromosome segregation as well as ensure genetic diversity in organisms. Defects in recombination often lead to… read more here.
Keywords: testis; histo morphological; expression rad51; cattle yak ... See more keywords
Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02239-4
Abstract: Breast cancer (BC) is the second cause of cancer-related deceases in the worldwide female population. Despite the successful treatment advances, 25% of BC develops resistance to current therapeutic regimens, thereby remaining a major hurdle for… read more here.
Keywords: sam68; rad51; breast cancer; inhibition ... See more keywords
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04261-0
Abstract: DNA double-stranded breaks (DSBs) are deleterious lesions, and their incorrect repair can drive cancer development 1 . HELQ is a superfamily 2 helicase with 3′ to 5′ polarity, and its disruption in mice confers germ… read more here.
Keywords: dna; rad51; strand annealing; rpa rad51 ... See more keywords
Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequences
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2007192118
Abstract: Significance Sexual eukaryotes fall into two groups with respect to their RecA-like recombinases. The first group possesses Rad51 (ubiquitous) and Dmc1 (meiosis-specific), which cooperate to conduct interhomolog recombination in zygotes with high sequence heterogeneity. Interestingly,… read more here.
Keywords: meiosis; trichoderma reesei; interhomolog recombination; trrad51 ... See more keywords
Determination of the number of RAD51 molecules in different human cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1691802
Abstract: ABSTRACT Knowledge about precise numbers of specific molecules is necessary for understanding and verification of biological pathways. The RAD51 protein is central in the repair of DNA double-strand breaks (DSBs) by homologous recombination repair and… read more here.
Keywords: cell lines; rad51 molecules; number rad51; human cell ... See more keywords