Abstract 5603: Defining the functions of the BRCA2 BRC repeats in modulating RAD51 binding and activity
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DOI: 10.1158/1538-7445.am2024-5603
Abstract: The BRCA2 (Breast Cancer Susceptibility 2) gene is critical for preserving genome integrity by regulating homology-directed repair (HDR) of DNA double-strand breaks (DSBs). Germline mutations in BRCA2 predispose individuals to a high risk for ovarian,… read more here.
Keywords: brc repeats; brc repeat; cancer; rad51 binding ... See more keywords
Abstract P5-06-06: The Mechanistic Role of BRCA1 DNA and RAD51 Binding in DNA Double-Strand Break Repair
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DOI: 10.1158/1557-3265.sabcs24-p5-06-06
Abstract: Genomic instability is a hallmark of cancer, enabling the generation of mutations and gross chromosomal rearrangements to drive neoplastic cell transformation and oncogenesis. The BRCA1-BARD1 protein complex acts to eliminate highly toxic DNA double-strand breaks,… read more here.
Keywords: dna rad51; rad51 binding; brca1; brca1 bard1 ... See more keywords