Saccharomyces cerevisiae Mus81–Mms4 and Rad52 can cooperate in the resolution of recombination intermediates
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DOI: 10.1002/yea.3320
Abstract: Mus81 is a well‐conserved DNA structure‐specific endonuclease which belongs to the XPF/Rad1 family of proteins that are involved in DNA nucleotide excision repair. Mus81 forms a heterodimer with a non‐catalytic subunit, Mms4, in Saccharomyces cerevisiae… read more here.
Keywords: saccharomyces cerevisiae; mms4; mus81 mms4; rad52 ... See more keywords
Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation
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DOI: 10.1038/s41467-019-09196-9
Abstract: Stabilisation of stalled replication forks prevents excessive fork reversal and their pathological degradation, which can undermine genome integrity. Here we investigate a physiological role of RAD52 at stalled replication forks by using human cell models… read more here.
Keywords: degradation; fork; prevents excessive; stalled replication ... See more keywords
RAD52 gene polymorphisms are associated with risk of colorectal cancer in a Chinese Han population
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DOI: 10.1097/md.0000000000008994
Abstract: Abstract Upward trends in the incidence and mortality rates of colorectal cancer (CRC) in China over the past decade mean that it is critical to improve survival outcomes for patients with this malignancy. Analysis of… read more here.
Keywords: risk; chinese han; polymorphisms associated; colorectal cancer ... See more keywords
Abstract B39: Small Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA Deficient Cancers
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DOI: 10.1158/1538-8514.synthleth-b39
Abstract: Suppression of RAD52 causes synthetic lethality in BRCA deficient cells. Yet pharmacological inhibition of RAD52, which binds single-strand DNA (ssDNA) and lacks enzymatic activity, has not been demonstrated. Here, we identify the small molecule 6-hydroxy-dopa… read more here.
Keywords: rad52; medicine; brca deficient; small molecule ... See more keywords
Rad52 deficiency decreases development of lung squamous cell carcinomas by enhancing immuno-surveillance
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DOI: 10.18632/oncotarget.16371
Abstract: RAD52 is involved in homologous recombination and DNA repair. This study focuses on lung cancer progression and how the DNA repair gene, Rad52, enables tumor cells to have sufficient genome integrity, i.e., the ability to… read more here.
Keywords: tumor; dna; squamous cell; rad52 ... See more keywords
Current Understanding of RAD52 Functions: Fundamental and Therapeutic Insights
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DOI: 10.3390/cancers12030705
Abstract: In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories… read more here.
Keywords: fundamental therapeutic; functions fundamental; rad52; understanding rad52 ... See more keywords
Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies
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DOI: 10.3390/cancers15061817
Abstract: Simple Summary Human RAD52 is a non-essential DNA/RNA-binding protein thought to be involved in many DNA repair mechanisms. Initially regarded as having a major role only in error-prone backup DNA repair mechanisms, RAD52 has recently… read more here.
Keywords: dna repair; rad52; inhibition; review ... See more keywords