Abstract 1149: Targeting Rad6B suppresses melanomagenesis
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1149
Abstract: Active β-catenin signaling in melanoma is associated with aggressive disease. We have previously shown that Rad6B, an ubiquitin conjugating enzyme, is a positive regulator of β-catenin stability and transcriptional activity, and is itself a transcriptional… read more here.
Keywords: melanoma; catenin; rad6b; rad6b suppresses ... See more keywords
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00392
Abstract: RAD6 participates in DNA double-strand breaks (DSBs) repair by ubiquitinating histone H2B in mitotic cells. In terminally differentiated cells, however, the mechanisms of DNA damage repair are less well known. In this study, we investigate… read more here.
Keywords: dna damage; rad6b deficient; rad6b; neurodegeneration ... See more keywords