Development of Biomarkers for Radiation Biodosimetry and Medical Countermeasures Research: Current Status, Utility, and Regulatory Pathways
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DOI: 10.1667/rade-21-00213.1
Abstract: Biomarkers are important indicators of biological processes in health or disease. Consequently, they play an important role in advancing development of radiation biodosimetry tools and in the development of medical countermeasures (MCMs) (1). They can… read more here.
Keywords: development; radiation biodosimetry; medical countermeasures; radiation ... See more keywords
Effect of the p38 Mitogen-Activated Protein Kinase Signaling Cascade on Radiation Biodosimetry
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DOI: 10.1667/rade-21-00240.1
Abstract: Radiation biodosimetry based on transcriptomic analysis of peripheral blood is a valuable tool to detect radiation exposure after a radiological/nuclear event and obtain useful biological information that could predict tissue and organismal injury. However, confounding… read more here.
Keywords: mitogen activated; p38 mitogen; radiation biodosimetry; radiation ... See more keywords
DosiKit, a New Immunoassay for Fast Radiation Biodosimetry of Hair and Blood Samples
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DOI: 10.1667/rr15136.1
Abstract: DosiKit is a field radiation biodosimetry immunoassay for fast triage of individuals exposed to external total-body or partial-body irradiation (TBI or PBI). Assay proof-of-concept based on γ-H2AX analysis of human blood samples has been previously… read more here.
Keywords: hair; immunoassay fast; blood; radiation biodosimetry ... See more keywords
Use of a Humanized Mouse Model System in the Validation of Human Radiation Biodosimetry Standards
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DOI: 10.1667/rr15283.1
Abstract: After a planned or unplanned radiation exposure, determination of absorbed dose has great clinical importance, informing treatment and triage decisions in the exposed individuals. Biodosimetry approaches allow for determination of dose in the absence of… read more here.
Keywords: radiation; mouse model; radiation biodosimetry; biodosimetry ... See more keywords