A new function for the serine protease HtrA2 in controlling radiation‐induced senescence in cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13187
Abstract: Radiation therapy can induce cellular senescence in cancer cells, leading to short‐term tumor growth arrest but increased long‐term recurrence. To better understand the molecular mechanisms involved, we developed a model of radiation‐induced senescence in cultured… read more here.
Keywords: htra2; senescence; radiation; radiation induced ... See more keywords
Smart Oral Administration of Polydopamine-Coated Nanodrugs for Efficient Attenuation of Radiation-Induced Gastrointestinal Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901778
Abstract: High-dose ionizing radiation can lead to death from the unrecoverable damage of the gastrointestinal tract, especially the small intestine. Until now, the lack of predilection for the small intestine and rapid clearance by digestive fluids… read more here.
Keywords: radiation induced; gastrointestinal syndrome; smart oral; oral administration ... See more keywords
Bioinspired and Inflammation‐Modulatory Glycopeptide Hydrogels for Radiation‐Induced Chronic Skin Injury Repair
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201671
Abstract: Clinical wound management of radiation‐induced skin injury (RSI) remains a great challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and the concomitant repetitive inflammatory microenvironment caused by an imbalance in macrophage… read more here.
Keywords: glycopeptide; inflammation; skin injury; radiation induced ... See more keywords
Bio-Inspired Antioxidant Heparin-Mimetic Peptide Hydrogel for Radiation-Induced Skin Injury Repair.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203387
Abstract: Radiotherapy is one of the most important means of cancer treatment, however, radiation can also cause adverse reactions and even serious injuries to the skin. Radiation-induced excess reactive oxygen species (ROS) production and inflammatory infiltration… read more here.
Keywords: skin injury; hydrogel; induced skin; radiation ... See more keywords
pH‐Responsive Probiotic‐Liposome Hybrid System Synergistically Treats Radiation‐Induced Injury via Dual Mechanisms of Anti‐Inflammatory and Microbiome Modulation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501642
Abstract: Radiation‐induced intestinal injury poses significant clinical challenges in radiotherapy. This study develops an oral pH‐responsive probiotic‐liposome hybrid system (EcNPIN‐L) by conjugating Escherichia coli Nissle 1917 (EcN) with pinocembrin (PIN)‐loaded liposomes (B‐Lip‐PIN) via biotin‐streptavidin binding and… read more here.
Keywords: system; radiation induced; responsive probiotic; injury ... See more keywords
Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short- and Long-Lived Radicals.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202502621
Abstract: Metallofullerenols (MFs), functionalized endohedral fullerenes, exhibit unique activity by integrating atomic, molecular, and supramolecular levels of matter organization. The antioxidant properties of MFs constitute a novel technology, utilizing these nanocompounds for radioprotection. This integration of… read more here.
Keywords: sc3n c80; radiation induced; damage; human erythrocytes ... See more keywords
METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N6 -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202204784
Abstract: The biological roles of epithelial-mesenchymal transition (EMT) in the pathogenesis of radiation-induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated. N6 -methyladenosine (m6 A) modification, the most abundant… read more here.
Keywords: ythdf2; modification; epithelial mesenchymal; radiation induced ... See more keywords
A Frog Skin‐Derived Peptide Targeting SCD1 Exerts Radioprotective Effects Against Skin Injury by Inhibiting STING‐Mediated Inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202306253
Abstract: The extensive application of nuclear technology has increased the potential of uncontrolled radiation exposure to the public. Since skin is the largest organ, radiation‐induced skin injury remains a serious medical concern. Organisms evolutionally develop distinct… read more here.
Keywords: radiation; radiation induced; rifsp; skin injury ... See more keywords
Aloe Emodin Alleviates Radiation‐Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406026
Abstract: Aloe emodin is an anthraquinone of traditional Chinese medicine monomer, which plays a protective action in cardiovascular diseases. However, the regulatory mechanisms of aloe emodin in the protection of radiation‐induced heart damage (RIHD) are unclear.… read more here.
Keywords: induced heart; radiation induced; lactylation; aloe emodin ... See more keywords
Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202509383
Abstract: The gut microbiota is key to mitigating ionizing radiation (IR)–induced injuries; however, the specific species involved in and the molecular mechanisms remain elusive. Mitochondrial dynamics affect gut microbiota diversity. To identify the specific species involved… read more here.
Keywords: radiation induced; butyrate; rodentium; faecalibaculum rodentium ... See more keywords
Low serum 25‐hydroxyvitamin D3 levels and late delayed radiation‐induced brain injury in patients with nasopharyngeal carcinoma: A case–control study
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1892
Abstract: Inflammatory reaction plays a critical role in the pathogenesis of late delayed radiation‐induced brain injury (RBI). Low vitamin D levels are closely associated with various immuno‐inflammatory diseases, but the relationship with late delayed RBI remains… read more here.
Keywords: induced brain; radiation induced; delayed radiation; late delayed ... See more keywords