Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.01.020
Abstract: Ionizing radiation (IR) and chemotherapy are standard-of-care treatments for glioblastoma (GBM) patients and both result in DNA damage, however, the clinical efficacy is limited due to therapeutic resistance. We identified a mechanism of such resistance… read more here.
Keywords: radiation sensitivity; pten tyrosine; dna repair; phosphorylation ... See more keywords
G0/G1 Switch 2 regulates a G1-lipid checkpoint dependent radiation sensitivity of human head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.143
Abstract: A recent study reports the presence of a G1-lipid checkpoint that is dysregulated in clear cell renal carcinoma. A defective G1-lipid checkpoint forces these cells to utilize lipids as their energy source. Head and neck… read more here.
Keywords: radiation sensitivity; carcinoma; lipid checkpoint; checkpoint ... See more keywords
Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118737
Abstract: AIM Our previous study has shown that leucine-rich repeat containing GPCR-4 (LGR4, or GPR48) LGR4 plays a role in cell migration, invasion, proliferation and apoptosis of prostate cancer (PCa). In this study, we aimed to… read more here.
Keywords: lgr4; radiation sensitivity; prostate cancer; expression ... See more keywords
Clinical and epidemiological observations on individual radiation sensitivity and susceptibility
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2019.1665209
Abstract: Abstract Purpose: To summarize existing knowledge and to understand individual response to radiation exposure, the MELODI Association together with CONCERT European Joint Programme has organized a workshop in March 2018 on radiation sensitivity and susceptibility.… read more here.
Keywords: radiation sensitivity; epidemiological observations; sensitivity susceptibility; clinical epidemiological ... See more keywords
Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-κB activating protein
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001358
Abstract: Exosomes, which are small extracellular vesicles, have been unveiled to carry circular RNAs (circRNAs). CircRNA paired-related homeobox 1 (circPRRX1) can be transferred by exosomes derived from gastric cancer cells. Here, we investigated the activity and… read more here.
Keywords: radiation sensitivity; mir 596; exosomal circprrx1; gastric cancer ... See more keywords
PO-133 Inhibition of HIF-1α enhances radiation sensitivity in tumour cells and mediates tumour growth decrease in mice
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.657
Abstract: Introduction Poor prognosis of many solid tumours is often associated with hypoxic regions and an increased level of hypoxia-inducible-factor-1α (HIF-1α). Previous findings indicate that HIF-1α expression is relevant for radiation resistance. It was shown that… read more here.
Keywords: radiation sensitivity; hif; hif deficient; inhibition ... See more keywords
Abstract 829: MicroRNA regulation of radiation sensitivity in colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-829
Abstract: Background Patients with locally advanced rectal cancer receive neoadjuvant chemoradiation therapy (CRT) and subsequent surgery. While 10-25% of patients have complete response to CRT, the remaining patients undergo extensive tumor excision resulting in significant quality… read more here.
Keywords: radiation sensitivity; response; colorectal cancer; cancer ... See more keywords
Abstract 2424: Development of radiation sensitivity evaluation platform in esophageal cancer patient derived organoids
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2424
Abstract: Radiation therapy (Radiotherapy) is a highly effective treatment with wide range of cancer curing. Radiotherapy allows the cancer cells to be killed or reduced in number while protecting the majority of other organs and tissues… read more here.
Keywords: evaluation; radiation sensitivity; esophageal cancer; radiation ... See more keywords
MiR-99a Enhances the Radiation Sensitivity of Non-Small Cell Lung Cancer by Targeting mTOR
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000488615
Abstract: Background/Aims: Radiation therapy is an important and effective modality for the treatment of non-small cell lung cancer (NSCLC). MicroRNAs (miRNAs) are crucial post-transcriptional regulators that are involved in numerous important biologic processes. However, their potential… read more here.
Keywords: radiation sensitivity; mir 99a; mtor; cancer ... See more keywords