Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85044-5
Abstract: Recent political unrest has highlighted the importance of understanding the short- and long-term effects of gamma-radiation exposure on human health and survivability. In this regard, effective treatment for acute radiation syndrome (ARS) is a necessity… read more here.
Keywords: acute radiation; radiation syndrome; drug; potential drug ... See more keywords
Delayed Renal Injury in Survivors of Hematologic Acute Radiation Syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2170491
Abstract: Purpose: A mass casualty disaster involving radiological or nuclear agents continues to be a public health concern which requires consideration of both acute and late tissue toxicities in exposed victims. With the advent of advanced… read more here.
Keywords: renal injury; acute radiation; radiation syndrome; delayed renal ... See more keywords
Sargramostim in acute radiation syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2143261
Abstract: ABSTRACT Introduction Since 1944, nearly 400 radiologic accidents/incidents have exposed about 3,000 people to substantial doses of ionizing radiation, with more than 125 deaths. Known are the Chernobyl and Fukushima nuclear power facility accidents, but… read more here.
Keywords: ionizing radiation; acute radiation; radiation syndrome; sargramostim ... See more keywords
The acute radiation syndrome—need for updated medical guidelines
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Radiological Protection"
DOI: 10.1088/1361-6498/ac4ac6
Abstract: The major immediate and severe medical consequences in man following exposure to high doses of ionising radiation can be summarised within the concept of the acute radiation syndrome (ARS). In a dose-dependent fashion, a multitude… read more here.
Keywords: acute radiation; radiation syndrome; medical guidelines; radiation ... See more keywords
COORDINATION OF MANAGEMENT OF THE ACUTE RADIATION SYNDROME.
Sign Up to like & getrecommendations! Published in 2018 at "Radiation protection dosimetry"
DOI: 10.1093/rpd/ncy144
Abstract: The acute radiation syndrome (ARS) constitutes the most challenging, immediate medical consequence of exposure to high doses of ionizing radiation in an emergency situation. This report highlights some of the currently available medical guidelines and… read more here.
Keywords: acute radiation; radiation syndrome; management acute; coordination management ... See more keywords
Use of Proteomic and Hematology Biomarkers for Prediction of Hematopoietic Acute Radiation Syndrome Severity in Baboon Radiation Models
Sign Up to like & getrecommendations! Published in 2018 at "Health Physics"
DOI: 10.1097/hp.0000000000000819
Abstract: Abstract Use of plasma proteomic and hematological biomarkers represents a promising approach to provide useful diagnostic information for assessment of the severity of hematopoietic acute radiation syndrome. Eighteen baboons were evaluated in a radiation model… read more here.
Keywords: hematopoietic acute; hematology; acute radiation; radiation syndrome ... See more keywords
Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI
Sign Up to like & getrecommendations! Published in 2019 at "Health Physics"
DOI: 10.1097/hp.0000000000000948
Abstract: Abstract The acute radiation syndrome of the gastrointestinal tract has been histologically characterized, but the molecular and functional mechanisms that lead to these cellular alterations remain enigmatic. Mass spectrometry imaging is the only technique that… read more here.
Keywords: syndrome gastrointestinal; gastrointestinal tract; mass; radiation syndrome ... See more keywords
Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model
Sign Up to like & getrecommendations! Published in 2019 at "Health Physics"
DOI: 10.1097/hp.0000000000000951
Abstract: Abstract Radiation exposure to the gastrointestinal system contributes to the acute radiation syndrome in a dose- and time-dependent manner. Molecular mechanisms that lead to the gastrointestinal acute radiation syndrome remain incompletely understood. Using a murine… read more here.
Keywords: total body; radiation; body irradiation; radiation syndrome ... See more keywords
Cholinergic and cytoprotective signaling cascades mediate the mitigative effect of erythropoietin on acute radiation syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2017-0578
Abstract: The present investigation aimed to evaluate the radiomitigative efficacy of the recombinant human erythropoietin (EPO) against acute radiation syndrome (ARS) in a rat model. Rats were irradiated with a single sublethal dose of γ-radiation (7… read more here.
Keywords: acute radiation; erythropoietin; radiation syndrome; radiation ... See more keywords
Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.145380
Abstract: After 9/11, threat of nuclear attack on American urban centers prompted government agencies to develop medical radiation countermeasures to mitigate hematopoietic acute radiation syndrome (H-ARS) and higher-dose gastrointestinal acute radiation syndrome (GI-ARS) lethality. While repurposing… read more here.
Keywords: anti ceramide; radiation syndrome; dna repair; repair ... See more keywords
An update on sargramostim for treatment of acute radiation syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Drugs of today"
DOI: 10.1358/dot.2018.54.11.2899370
Abstract: The potential use by terrorists of an improvised nuclear device, a radiological dispersal device, or an unintended nuclear/radiological accident in heavily populated areas is a national security threat of major consequences. Although this type of… read more here.
Keywords: acute radiation; treatment; radiation syndrome; update sargramostim ... See more keywords