Visible-Light Mediated Radical Alkylation of Flavones: A Modular Access to Nonsymmetrical 3,3″-Biflavones.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03415
Abstract: The first synthetic strategy for nonsymmetrical 3,3″-biflavones is described. To this end, a novel visible-light iridium-catalyzed radical C-3 alkylation of flavones with o-methoxy phenacyl bromides was developed. Selective demethylation of the alkylated flavones and acylation… read more here.
Keywords: nonsymmetrical biflavones; radical alkylation; alkylation flavones; visible light ... See more keywords
Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c03607
Abstract: Substituted arenes are ubiquitous in molecules with medicinal functions, making their synthesis a critical consideration when designing synthetic routes. Regioselective C-H functionalization reactions are attractive for preparing alkylated arenes; however, the selectivity of existing methods… read more here.
Keywords: alkylation arenes; arenes using; alkylation; radical alkylation ... See more keywords
Direct radical alkylation and acylation of 2H-indazoles using substituted Hantzsch esters as radical reservoirs
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00507j
Abstract: A platform approach for the direct synthesis of 3-substituted 2H-indazole derivatives has been developed using a Ag(I)/Na2S2O8 system. This regioselective alkylation/acylation protocol operates under mild conditions, tolerates a wide range of structural moieties and delivers… read more here.
Keywords: radical alkylation; acylation indazoles; alkylation acylation; direct radical ... See more keywords