Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidenechromene Derivatives.
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DOI: 10.1021/acs.orglett.0c03946
Abstract: A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed. The reaction shows broad substrate scope, wide functional group tolerance, and… read more here.
Keywords: arylsulfonyl methyl; synthesis arylsulfonyl; radical annulation; free radical ... See more keywords
Modular Access to 2-(Trifluoromethyl)pyrazolo[1,5-a]pyridines and Their Benzo Analogues through a Copper(I)-Catalyzed Radical Annulation.
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DOI: 10.1021/acs.orglett.2c02500
Abstract: A mechanistically distinctive copper-catalyzed radical annulation to valuable 2-(trifluoromethyl)pyrazolo[1,5-a]pyridines and their benzo analogues has been described for the first time. Notably, the newly developed complementary process allows the synthesis of 4- or 6-substituted target molecular… read more here.
Keywords: pyridines benzo; catalyzed radical; radical annulation; pyrazolo pyridines ... See more keywords
Photocatalytic Regioselective [2 + 2 + 1] Radical Annulation of Alkenes with tert-Butyl Nitrite and gem-Dihalides.
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DOI: 10.1021/acs.orglett.2c03635
Abstract: A visible-light photocatalytic regioselective [2 + 2 + 1] radical annulation reaction of alkenes, tert-butyl nitrite, and gem-dihalides has been developed. The protocol provides an efficient and practical approach to obtain isoxazolines in good yields… read more here.
Keywords: gem dihalides; butyl nitrite; radical annulation; photocatalytic regioselective ... See more keywords