Radical C4–H Arylation of 1,4‐Dihydropyridines with Cyanoarenes
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DOI: 10.1002/hlca.202400162
Abstract: 4‐Aryl‐1,4‐dihydropyridines are prevalent pharmacophores and versatile building blocks in medicinal and synthetic chemistry. Herein, we demonstrated a mechanistically distinct radical‐radical cross‐coupling approach to 4‐aryl‐1,4‐dihydropyridines, via direct C4–H arylation of 1,4‐dihydropyridines with readily available cyanoarenes. This… read more here.
Keywords: arylation dihydropyridines; chemistry; dihydropyridines cyanoarenes; radical arylation ... See more keywords
Radical C-H Arylation of Oxazoles with Aryl Iodides: dppf as an Electron-Transfer Mediator for Cs2CO3.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00530
Abstract: A radical C-H arylation reaction of oxazoles with (hetero)aryl iodides using Cs2CO3 as base/electron donor and 1,1'-bis(diphenylphosphino) ferrocene (dppf) as a catalytic SET mediator is reported. The overall reaction likely follows the general base-promoted homolytic… read more here.
Keywords: mediator; aryl iodides; radical arylation; electron ... See more keywords
Palladium-catalyzed radical arylation of N-hydroxyphthalimides with triphenyl phosphites as an unusual arylating agent via C(sp2)–O bond cleavage
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo01919e
Abstract: An approach has been developed for producing aryl radical intermediates by utilizing readily accessible triphenyl phosphite as the radical precursor in a Pd-catalyst system under air conditions. Moreover, the possible mechanism was proposed. read more here.
Keywords: catalyzed radical; palladium catalyzed; arylation hydroxyphthalimides; radical arylation ... See more keywords
Photocatalytic radical arylation/cyclization of N-arylacrylamides to 3-benzyl oxindoles
Sign Up to like & getrecommendations! Published in 2025 at "Mendeleev Communications"
DOI: 10.71267/mencom.7798
Abstract: A photocatalytic tandem radical arylation/cyclization of N-arylacrylamides with diaryliodonium triflates at room temperature affords 3-(benzyl)oxindoles in moderate to good yields. The diaryliodonium triflates upon blue visible light irradiation in the presence of Ir(ppy)2(dtbbpy) · PF6… read more here.
Keywords: radical arylation; cyclization arylacrylamides; cyclization; benzyl oxindoles ... See more keywords