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   Articles with "radical cascade" as a keyword



AIBN‐Mediated Radical Cascade Synthesis of Maleimide‐Fused Thiochromenes

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recommendations! Published in 2025 at "Asian Journal of Organic Chemistry"

DOI: 10.1002/ajoc.202500480

Abstract: A radical cascade reaction has been established for the efficient synthesis of an entirely new class of heterocycles, i.e., maleimides‐fused thiochromenes. The cascade reaction between aryl thiols and styryl diazo imides is initiated by a… read more here.

Keywords: radical cascade; mediated radical; synthesis; fused thiochromenes ... See more keywords

Radical Cascade Annulation of Biphenyl Acrylamides to Dibenzoazepinones: Experimental and DFT Studies

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recommendations! Published in 2024 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202400450

Abstract: An efficient method for the conversion of biphenyl acrylamides to dibenzoazepinones with ‐SCF3 incorporation is described. This operationally simple radical cascade reaction employs CAN as an oxidant and exhibits good functional group tolerance. Substrates featuring… read more here.

Keywords: acrylamides dibenzoazepinones; biphenyl acrylamides; cascade annulation; radical cascade ... See more keywords

Visible Light‐Induced the Radical Cascade Cyclization of 2‐Isocyanobiaryls via 1,2‐Hydrogen Atom Transfer

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recommendations! Published in 2025 at "European Journal of Organic Chemistry"

DOI: 10.1002/ejoc.202500735

Abstract: Phenanthridines, as important structural moieties of many naturally occurring products, pharmaceuticals, and functionalized polycyclic heteroarenes, have attracted considerable attention among chemists due to their significant potential in pharmaceutical and material chemistry. The hydrogen atom transfer… read more here.

Keywords: chemistry; isocyanobiaryls via; radical cascade; cyclization isocyanobiaryls ... See more keywords
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Ag-S Type Quantum Dots versus Superatom Nanocatalyst: A Single Sulfur Atom Modulated Decarboxylative Radical Cascade Reaction.

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recommendations! Published in 2023 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.3c00070

Abstract: The preparation of high-nuclearity silver nanoclusters in quantitative yield remains exclusive and their potential applications in the catalysis of organic reactions are still undeveloped. Here, we have synthesized a quantum dot (QD)-based catalyst, [Ag62S13(SBut)32](PF6)4 (denoted… read more here.

Keywords: reaction; atom; spectroscopy; radical cascade ... See more keywords
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Photoredox Catalysis toward 2-Sulfenylindole Synthesis through a Radical Cascade Process.

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recommendations! Published in 2020 at "Organic letters"

DOI: 10.1021/acs.orglett.0c01297

Abstract: A radical cascade process initiated through visible-light induced thiyl radical coupling with ortho-substituted arylisocianides followed by an intramolecular cyclization and subsequent aromatization to access 2-sulfenylindoles is described. The key thiyl radicals are promptly generated via… read more here.

Keywords: radical cascade; cascade process; process; catalysis toward ... See more keywords

Chemoselective Synthesis of 3-Bromomethyloxindoles via Visible-Light-Induced Radical Cascade Bromocyclization of Alkenes.

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recommendations! Published in 2024 at "Organic letters"

DOI: 10.1021/acs.orglett.4c01105

Abstract: A novel visible-light-induced radical cascade bromocyclization of N-arylacrylamides has been accomplished. This reaction overcomes the overbromination at the benzene rings suffered in traditional electrophilic reactions, thus enabling the first highly chemoselective synthesis of valuable 3-bromomethyloxindoles.… read more here.

Keywords: radical cascade; visible light; chemoselective synthesis; light induced ... See more keywords

Photoinduced Copper-Catalyzed Radical Cascade Sonogashira-Type Coupling of Unsaturated Oxime Esters with Alkynes.

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recommendations! Published in 2025 at "Organic letters"

DOI: 10.1021/acs.orglett.5c03435

Abstract: A photoinduced copper-catalyzed radical cascade Sonogashira-type coupling of unsaturated oxime esters with terminal alkynes has been developed. The transformation proceeds under redox-neutral conditions via single-electron transfer (SET) from photoexcited Cu(I) acetylides, generating iminyl radicals that… read more here.

Keywords: cascade sonogashira; catalyzed radical; radical cascade; photoinduced copper ... See more keywords

Electrophotocatalytic Radical Cascade Reaction for the Synthesis of Trifluoromethylated Spirocyclobutyl Oxindoles.

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recommendations! Published in 2025 at "Organic letters"

DOI: 10.1021/acs.orglett.5c03594

Abstract: We report an electrophotocatalytic strategy for the radical fluoroalkylation and spirocyclization of bicyclo[1.1.0]butanes. This synergistic method leverages the energy of electricity and light to generate fluoroalkyl radicals from inexpensive Langlois' reagents under mild, metal-free conditions.… read more here.

Keywords: radical cascade; electrophotocatalytic radical; cascade reaction; reaction synthesis ... See more keywords

Free-Radical Cascade Generated by AIPH/Fe3O4-Coloaded Nanoparticles Enhances MRI-Guided Chemo/Thermodynamic Hypoxic Tumor Therapy.

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recommendations! Published in 2022 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.2c05748

Abstract: Free radicals, including reactive oxygen species (ROS), play a critical role in determining cell's fate. When the level of free radicals is increased to a fatal value, it causes cancer cells to undergo senescence or… read more here.

Keywords: therapy; free radicals; radical cascade; free radical ... See more keywords

Total Synthesis of Puberuline C.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c11259

Abstract: Puberuline C (1) is an architecturally complex C19-diterpenoid alkaloid with a unique ring fusion pattern. The 6/7/5/6/6/6-membered rings (ABCDEF-rings) contain one tertiary amine and six oxygen functionalities, and possess 12 contiguously aligned stereocenters, three of… read more here.

Keywords: total synthesis; synthesis puberuline; synthesis; radical cascade ... See more keywords

Radical Cascade Dissociation Pathways to Unusual Nucleobase Cation Radicals.

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recommendations! Published in 2022 at "Journal of the American Society for Mass Spectrometry"

DOI: 10.1021/jasms.2c00098

Abstract: We report unusual dissociations of protonated RNA nucleosides tagged with radical initiator groups at ribose 5'-O and furnished with a 2',3'-O-isopropylidene protecting group. The ions undergo collision-induced radical cascade dissociations starting at the radical initiator… read more here.

Keywords: cation radicals; cascade; cascade dissociations; radical cascade ... See more keywords