Engineered P450 Atom-Transfer Radical Cyclases are Bifunctional Biocatalysts: Reaction Mechanism and Origin of Enantioselectivity.
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DOI: 10.1021/jacs.2c04937
Abstract: New-to-nature radical biocatalysis has recently emerged as a powerful strategy to tame fleeting open-shell intermediates for stereoselective transformations. In 2021, we introduced a novel metalloredox biocatalysis strategy that leverages the innate redox properties of the… read more here.
Keywords: transfer radical; enantioselectivity; atom transfer; mechanism ... See more keywords