Theoretical insight into the reaction mechanism of hydroxyl radical and guanine in G-quadruplex DNA
Sign Up to like & getrecommendations! Published in 2023 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d3cp01772a
Abstract: A DFT investigation was performed to illuminate the obscure mechanism of hydroxyl radical (OH˙) and guanine in G-quadruplex by mapping the energy profiles for both addition and hydrogen abstraction reactions. Results revealed that in G-quadruplex,… read more here.
Keywords: mechanism hydroxyl; hydroxyl radical; guanine quadruplex; radical guanine ... See more keywords
A TD-DFT-Based Study on the Attack of the OH· Radical on a Guanine Nucleotide
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DOI: 10.3390/ijms231710007
Abstract: Heavy charged particles induce severe damage in DNA, which is a radiobiological advantage when treating radioresistant tumors. However, these particles can also induce cancer in humans exposed to them, such as astronauts in space missions.… read more here.
Keywords: dna; dft; attack radical; guanine nucleotide ... See more keywords