Enantioselective Radical Hydroacylation of Enals with α-Ketoacids Enabled by Photoredox/Amine Cocatalysis.
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DOI: 10.1021/acs.orglett.8b03840
Abstract: A photoredox/amine-cocatalyzed enantioselective radical hydroacylation of enals with α-ketoacids is described. Acyl radicals generated from α-ketoacids act as the acylation reagent with the iminium ions. This strategy provides an efficient way to access synthetically challenging… read more here.
Keywords: enals ketoacids; photoredox amine; enantioselective radical; hydroacylation enals ... See more keywords