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   Articles with "radical relay" as a keyword



Radical relay‐driven HMF oxidation enabled by single‐atom Co‐N‐C catalysts at low temperature and ambient pressure

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recommendations! Published in 2025 at "AIChE Journal"

DOI: 10.1002/aic.70053

Abstract: The 5‐hydroxymethylfurfural (HMF) oxidation to 2,5‐furandicarboxylic acid (FDCA) is a pivotal reaction in biomass refinery; however, it is challenged by harsh reaction conditions and suboptimal reaction kinetics. In this study, we propose a “radical relay… read more here.

Keywords: pressure; relay driven; hmf oxidation; radical relay ... See more keywords
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N-9 Alkylation of purines via light-promoted and metal-free radical relay

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recommendations! Published in 2018 at "Chinese Chemical Letters"

DOI: 10.1016/j.cclet.2017.08.005

Abstract: Abstract A metal-free and light-promoted approach to the synthesis of N -9 alkylated purine nucleoside derivatives, via a CF 3 radical triggered radical relay pathway, has been developed. Purine nucleoside derivatives were prepared regioselectively in… read more here.

Keywords: alkylation purines; metal free; radical relay; light promoted ... See more keywords

Redox Neutral Radical-Relay Cobalt Catalysis toward C-H Fluorination and Amination.

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recommendations! Published in 2020 at "Organic letters"

DOI: 10.1021/acs.orglett.0c01072

Abstract: A redox neutral radical-relay cobalt-catalyzed intramolecular C-H fluorination of N-fluoroamides featuring the in situ formed cobalt fluorides as the latent radical fluorinating agents is reported. Moreover, the reactivity of such a cobalt catalysis could be… read more here.

Keywords: cobalt; fluorination; redox neutral; neutral radical ... See more keywords
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N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Synthesis of δ-Ketocarbonyls.

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recommendations! Published in 2020 at "Organic letters"

DOI: 10.1021/acs.orglett.0c01199

Abstract: An NHC-catalyzed radical relay enabled the vicinal alkylacylation of alkenes using aldehydes and tertiary α-bromo esters as a versatile route to δ-keto esters bearing an all-carbon quaternary center at the position α to the ester.… read more here.

Keywords: relay enabling; catalyzed radical; carbene catalyzed; radical relay ... See more keywords
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Copper and Photocatalytic Radical Relay Enabling Fluoroalkylphosphorothiolation of Alkenes: Modular Synthesis of Fluorine-Containing S-Alkyl Phosphorothioates and Phosphorodithioates.

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recommendations! Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c03608

Abstract: A photoredox and copper-catalyzed fluoroalkylphosphorothiolation of activated and unactivated alkenes via a radical relay mechanism is reported. By employing fluoroalkyl halides as radical precursors and P(O)SH or P(S)SH compounds as coupling partners, a wide range… read more here.

Keywords: copper photocatalytic; phosphorothioates phosphorodithioates; fluoroalkylphosphorothiolation; alkyl phosphorothioates ... See more keywords

Synthesis of β-Thiolated-α-arylated Ketones Enabled by Photoredox and N-Heterocyclic Carbene-Catalyzed Radical Relay of Alkenes with Disulfides and Aldehydes.

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recommendations! Published in 2022 at "Organic letters"

DOI: 10.1021/acs.orglett.2c01915

Abstract: β-Thiolated-α-arylated ketones are perversive in bioactive molecules and serve as potential bidentate ligands for catalysis. Herein, a straightforward protocol to access β-thiolated ketones from aldehydes, alkenes, and disulfides enabled by the combination of photocatalysis and… read more here.

Keywords: radical relay; arylated ketones; thiolated arylated; alkenes disulfides ... See more keywords

Photoinduced Nitrogen-to-Alkyl Radical Relay Heck Reaction of o-Alkylbenzamides with Vinyl Arenes by Palladium Catalysis.

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recommendations! Published in 2023 at "Organic letters"

DOI: 10.1021/acs.orglett.3c01030

Abstract: Here, a palladium-catalyzed photoinduced N-to-alkyl radical relay Heck reaction of o-alkylbenzamides at benzylic sites with vinyl arenes is described. The reaction employs neither exogeneous photosensitizers nor external oxidants. It is proposed to proceed via a… read more here.

Keywords: alkyl radical; heck reaction; reaction; radical relay ... See more keywords

Photoinduced Radical Relay Reaction of 2-Methylthiolated Phenylacetylenes/Alkynones Initiated by Electron Donor-Acceptor Complexes.

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recommendations! Published in 2024 at "Organic letters"

DOI: 10.1021/acs.orglett.4c04230

Abstract: A method was found to construct sulfur-containing five- and six-membered heterocyclic alkyl sulfonyl compounds by using visible light and free radicals activated and/or generated by EDA complexes/homolytic cleavage as initiators to stimulate the relay reaction… read more here.

Keywords: relay; relay reaction; reaction methylthiolated; radical relay ... See more keywords

Visible Light-Driven Interrupted Barton Reaction: Intermolecular Radical-Relay Sulfonyloximation of Alkenes with DABSO and Alkyl Nitrites.

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recommendations! Published in 2024 at "Organic letters"

DOI: 10.1021/acs.orglett.4c04257

Abstract: A visible light-driven, intermolecular interrupted Barton reaction has been developed for radical-relay sulfonyloximation of alkenes with alkyl nitrites, using DABSO as a trapping reagent. This method overcomes the challenges of competing normal Barton reactions and… read more here.

Keywords: barton reaction; visible light; interrupted barton; barton ... See more keywords

A Visible-Light Organophotoredox-Catalyzed anti-Markovnikov Hydrocarbamoylation of Unactivated Alkene and Cyclization Cascade via Radical Relay.

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recommendations! Published in 2025 at "Organic letters"

DOI: 10.1021/acs.orglett.5c02878

Abstract: An organophotoredox-catalyzed anti-Markovnikov addition of the carbamoyl radical generated through the homolytic cleavage of 4-carbamoyl-1,4-dihydropyridine to the challenging unactivated alkene has been developed. Interestingly, the amino acid-derived carbamoyl precursor provided a unique opportunity for N-terminus… read more here.

Keywords: anti markovnikov; catalyzed anti; organophotoredox catalyzed; radical relay ... See more keywords

Synthesis of 3-(Methylsulfonyl)benzo[ b]thiophenes from Methyl(2-alkynylphenyl)sulfanes and Sodium Metabisulfite via a Radical Relay Strategy.

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recommendations! Published in 2019 at "Organic letters"

DOI: 10.1021/acs.orglett.9b00100

Abstract: A radical relay strategy for the generation of 3-(methylsulfonyl)benzo[ b]thiophenes through a reaction of methyl(2-alkynylphenyl)sulfanes with sodium metabisulfite in the presence of a photocatalyst under visible light irradiation is developed. This photoinduced sulfonylation proceeds efficiently… read more here.

Keywords: relay; radical relay; sodium; relay strategy ... See more keywords