Nanoprecipitation and Drug Delivery with PMTC: Toward Biomedical Application of Polyesters from Radical Ring-Opening Polymerization.
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202500432
Abstract: Polymerized cyclic ketene acetals (PCKAs) prepared by radical ring-opening polymerization (RROP) have shown tremendous potential in the biomedical field. In this work, the field is expanded to the formation of fully degradable nanoparticles (NPs) from… read more here.
Keywords: radical ring; drug delivery; ring opening; drug ... See more keywords
Current Standing on Radical Ring-Opening Polymerisations of Cyclic Ketene Acetals as Homopolymers and Copolymers with one Another.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200941
Abstract: Radical Ring-opening polymerisation (RROP) of cyclic ketene acetals (CKAs) emerges to be a valuable polymerisation technique. In attracting more attention, RROP has seen a new spike in publications, which we will put into perspective. This… read more here.
Keywords: homopolymers copolymers; cyclic ketene; radical ring; ketene acetals ... See more keywords
Degradable Glycopolyester-like Nanoparticles by Radical Ring-Opening Polymerization.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00851
Abstract: A small library of degradable polyester-like glycopolymers was successfully prepared by the combination of radical ring-opening copolymerization of 2-methylene-1,3-dioxepane as a cyclic ketene acetal (CKA) with vinyl ether (VE) derivatives and a Pd-catalyzed thioglycoconjugation. The… read more here.
Keywords: glycopolyester like; degradable glycopolyester; nanoparticles radical; radical ring ... See more keywords
Kinetic Model of Radical Ring-Opening Polymerization of Asymmetric Five-Membered Cyclic Ketene Acetals
Sign Up to like & getrecommendations! Published in 2025 at "Macromolecules"
DOI: 10.1021/acs.macromol.5c01438
Abstract: Radical ring-opening polymerization RROP of cyclic ketene acetals (CKAs) provides a promising route to biodegradable polyesters. However, the mechanistic factors determining polymer structure are still not well understood, especially for CKAs with asymmetricly substituted rings.… read more here.
Keywords: radical ring; opening polymerization; cyclic ketene; ring opening ... See more keywords
Isolation of Epimers in the Synthesis of Vinylcyclopropane Bearing Two Alanine Moieties and Their Radical Ring-Opening Polymerization
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecules"
DOI: 10.1021/acs.macromol.6b02778
Abstract: By condensing 1,1-dicarboxy-2-vinylcyclopropane with l-alanine methyl ester, a new chiral vinylcyclopropane derivative bearing two amide moieties 1 was synthesized. The vinylcyclopropane thus prepared was separated into two epimers, namely, RSS-1 and SSS-1. Both the epimers… read more here.
Keywords: ring opening; rrop; polymerization; opening polymerization ... See more keywords
Radical Ring-Opening Fluorosulfonylation of Methylenecyclobutanols via Electron Donor-Acceptor Photoactivation.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01989
Abstract: A visible-light-mediated catalyst- and additive-free method for radical ring-opening fluorosulfonylation of methylenecyclobutanols is reported. Sulfuryl chlorofluoride acts as a FSO2 radical precursor as well as an electron acceptor to form electron donor-acceptor complexes with various… read more here.
Keywords: fluorosulfonylation methylenecyclobutanols; radical ring; donor acceptor; ring opening ... See more keywords
Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.2c00298
Abstract: Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging… read more here.
Keywords: opening copolymerization; polyampholytes radical; radical ring; degradable polyampholytes ... See more keywords
Degradable N-Vinyl Copolymers through Radical Ring-Opening Polymerization of Cyclic Thionocarbamates
Sign Up to like & getrecommendations! Published in 2024 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.4c00550
Abstract: A thiocarbonyl radical ring-opening polymerization approach was implemented with cyclic thionocarbamates to generate degradable copolymers with N-vinyl monomers. The rigid structures of cyclic N-substituted thionocarbamates have been revealed by X-ray crystallography and NMR spectroscopy. The… read more here.
Keywords: radical ring; opening polymerization; ring opening; cyclic thionocarbamates ... See more keywords
Degradable Diblock Copolymer Vesicles via Radical Ring-Opening Polymerization-Induced Self-Assembly in Aqueous Media.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c03744
Abstract: The development of degradable polymeric vesicles is essential for next-generation controlled delivery systems and responsive materials, particularly for therapy and diagnostics. However, achieving precise control over their synthesis and degradation behavior remains a significant challenge.… read more here.
Keywords: copolymer; radical ring; diblock copolymer; aqueous media ... See more keywords
Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02256a
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Science"
DOI: 10.1039/c8sc02256a
Abstract: Degradable polymer prodrugs were synthesized by ‘drug-initiated’ nitroxide-mediated radical ring-opening copolymerization and led to either nanoparticles or soluble prodrugs with adjustable cytotoxicity on two different cancer cell lines. read more here.
Keywords: drug initiated; ring opening; opening copolymerization; radical ring ... See more keywords
Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Polymer Chemistry"
DOI: 10.1039/c9py01103j
Abstract: We report the first amine-bearing cyclic ketene acetals (CKAs) for radical ring-opening polymerisation (RROP). The resulting polyesters and their corresponding nanoparticles were biodegradable and showed the desired pH sensitive behaviour. read more here.
Keywords: ring opening; opening polymerisation; monomers radical; radical ring ... See more keywords