Radical C(sp3)-S Coupling for the Synthesis of α-Amino Sulfides.
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DOI: 10.1021/acs.orglett.3c01121
Abstract: A unique transition-metal-free radical thiolation of 2-azaallyl anions has been developed. Easily accessible thiosulfonates and 2-azaallyls undergo the tandem process of single-electron transfer and radical-radical coupling to construct C(sp3)-S bonds. This robust protocol enables a… read more here.
Keywords: sp3 coupling; coupling synthesis; amino sulfides; radical sp3 ... See more keywords