Synthesis of 2-Pyrrolidinone Derivatives via N-Heterocyclic Carbene Catalyzed Radical Tandem Cyclization/Coupling Reaction
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00544e
Abstract: Herein, a practical, convenient and facile protocol to construct highly functionalized 2-pyrrolidinone enabled by N-Heterocyclic Carbene(NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method... read more here.
Keywords: radical tandem; catalyzed radical; tandem cyclization; pyrrolidinone ... See more keywords
Photoinduced radical tandem annulation of 1,7-diynes: an approach for divergent assembly of functionalized quinolin-2(1H)-ones
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2024.1371978
Abstract: The first photocatalytic trichloromethyl radical-triggered annulative reactions of amide-linked 1,7-diynes with polyhalomethanes were established for the flexible assembly of functionalized quinolin-2(1H)-ones with generally acceptable yields. With the installation of the aryl group (R1) into the… read more here.
Keywords: radical tandem; assembly functionalized; functionalized quinolin; tandem annulation ... See more keywords