Selective Radical Trifluoromethylation of Native Residues in Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10230
Abstract: The incorporation of fluorine can not only significantly facilitate the study of proteins but also potentially modulate their function. Though some biosynthetic methods allow global residue-replacement, post-translational fluorine incorporation would constitute a fast and efficient… read more here.
Keywords: selective radical; trifluoromethylation; residues proteins; radical trifluoromethylation ... See more keywords
Visible light-induced aryltrifluoromethylation of hydroxy alkenes via radical trifluoromethylation-triggered aryl and heteroaryl migration
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c8qo00430g
Abstract: An efficient protocol was developed to achieve the aryltrifluoroalkylation of hydroxy alkenes via radical trifluoromethylation-triggered aryl migration. This method possesses several interesting features: (I) visible light is used as the sole promoter; (II) a new… read more here.
Keywords: hydroxy alkenes; alkenes via; radical trifluoromethylation; migration ... See more keywords
Synthesis of N-CF3 hydrazines through radical trifluoromethylation of azodicarboxylates.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04538e
Abstract: We report here the synthesis of a novel family of N-CF3 hydrazines from a direct way involving the available and cheap Langlois reagent (CF3SO2Na). These derivatives have shown very high stability whatever the conditions used… read more here.
Keywords: cf3 hydrazines; hydrazines radical; radical trifluoromethylation; cf3 ... See more keywords
Reduction of SF5CF3via iridium catalysis: radical trifluoromethylation of aromatics.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00495c
Abstract: The greenhouse gas SF5CF3 acts as CF3 source for the photocatalytic trifluoromethylation of arenes on using [Ir(dtbbpy)(ppy)2]PF6 (4,4'-di-tert-butyl-2,2'-dipyridyl, ppy = 2-phenylpyridine) as catalyst. The trifluoromethylation of C6D6 in the presence of 1-octanol results in the… read more here.
Keywords: catalysis radical; radical trifluoromethylation; sf5cf3via iridium; reduction sf5cf3via ... See more keywords