Abstract 1091: MDM2 inhibition as a novel radio-sensitizing strategy for endometrial cancer
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DOI: 10.1158/1538-7445.am2023-1091
Abstract: Introduction: As opposed to other malignancies, the majority of endometrial cancer (EC) cases are wild-type for TP53. Approximately 15% of TP53-mutated EC have heterozygous mutation, preserving a fraction of wild-type signaling. Given the demonstrated impact… read more here.
Keywords: cell; radio sensitizing; mdm2 inhibition; tp53 ... See more keywords
Abstract 2819: Genome-wide CRISPR screen identifies NANP as a radio-sensitizing target of GBM by regulating NF-κB pathway
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DOI: 10.1158/1538-7445.am2023-2819
Abstract: Glioblastoma multiforme (GBM) are the most malignant primary central nervous system tumors. The standard of care for newly diagnosed GBM patients includes surgery followed by combined radiation therapy (RT) and adjuvant temozolomide (TMZ) therapy. However,… read more here.
Keywords: crispr screen; genome wide; radio sensitizing; sensitizing target ... See more keywords