Time for radioimmunotherapy: an overview to bring improvements in clinical practice
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-018-02027-1
Abstract: Harnessing the patient’s own immune system against an established cancer has proven to be a successful strategy. Within the last years, several antibodies blocking critical “checkpoints” that control the activation of T cells, the immune… read more here.
Keywords: bring improvements; time radioimmunotherapy; overview bring; anti tumour ... See more keywords
Immuno-PET Imaging and Radioimmunotherapy of Lymphomas.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00563
Abstract: Monoclonal antibodies (Ab) have revolutionized the management of lymphomas, the most common hematologic malignancy in adults. Indeed, incorporation of rituximab into the regimen for indolent non-Hodgkin's lymphomas (NHLs) has dramatically improved treatment response and disease… read more here.
Keywords: pet; immuno pet; lymphomas; radioimmunotherapy ... See more keywords
Toward the Optimization of Click-Mediated Pretargeted Radioimmunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00062
Abstract: Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder reaction has shown promise in murine models of disease, yet the radiation dosimetry of this approach must be optimized to make it a viable clinical… read more here.
Keywords: optimization click; pretargeted radioimmunotherapy; toward optimization; absorbed dose ... See more keywords
FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208506119
Abstract: Significance Tumor immunotherapy synergized with radiotherapy (RT) has become promising for eradicating multiple advanced tumors. However, accompanying treatment-related detrimental events in normal tissues has been the dark side of the combination regimen, for patients potentially… read more here.
Keywords: radioimmunotherapy; flash ray; pyroptosis; ray spares ... See more keywords
Therapeutic efficacy evaluation of radioimmunotherapy with 90Y‐labeled anti‐podoplanin antibody NZ‐12 for mesothelioma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.13979
Abstract: Podoplanin is a type I transmembrane sialomucin‐like glycoprotein that is highly expressed in malignant mesothelioma. The rat‐human chimeric antibody NZ‐12 has high affinity for human podoplanin and antibody‐dependent cellular cytotoxicity and is applicable for radioimmunotherapy… read more here.
Keywords: 90y labeled; mesothelioma; podoplanin; podoplanin antibody ... See more keywords
ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2019-000340
Abstract: Background Radioimmunotherapy has a promising antitumor effect in hepatocellular carcinoma (HCC), depending on the regulatory effect of radiotherapy on tumor immune microenvironment. Ionizing radiation (IR)-induced DNA damage repair (DDR) pathway activation leads to the inhibition… read more here.
Keywords: radiotherapy; effect; immune microenvironment; radioimmunotherapy ... See more keywords
Yttrium-90-Ibritumomab Tiuxetan (Zevalin®) Radioimmunotherapy after Cytoreduction with ESHAP Chemotherapy in Patients with Relapsed Follicular Non-Hodgkin Lymphoma: Final Results of a Phase II Study
Sign Up to like & getrecommendations! Published in 2018 at "Oncology"
DOI: 10.1159/000486788
Abstract: Background: Radioimmunotherapy (RIT) is effective in treating relapsed/refractory follicular lymphoma (FL), with durable remissions in first-line consolidation. We hypothesized that RIT with ibritumomab tiuxetan (Zevalin®) would result in durable remissions by eliminating minimal residual disease… read more here.
Keywords: zevalin; tiuxetan zevalin; disease; ibritumomab tiuxetan ... See more keywords
Gut microbiota: A novel and potential target for radioimmunotherapy in colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1128774
Abstract: Colorectal cancer (CRC) is one of the most common cancers, with a high mortality rate, and is a major burden on human health worldwide. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites,… read more here.
Keywords: radioimmunotherapy; colorectal cancer; microbiota; gut microbiota ... See more keywords
Radioimmunotherapy for Brain Metastases: The Potential for Inflammation as a Target of Choice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.714514
Abstract: Brain metastases (BM) are frequently detected during the follow-up of patients with malignant tumors, particularly in those with advanced disease. Despite a major progress in systemic anti-cancer treatments, the average overall survival of these patients… read more here.
Keywords: brain metastases; inflammation; target; rit ... See more keywords
Development of In Vitro Assays for Advancing Radioimmunotherapy against Brain Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081796
Abstract: Glioblastoma (GBM) is the most common primary brain tumor. Due to high resistance to treatment, local invasion, and a high risk of recurrence, GBM patient prognoses are often dismal, with median survival around 15 months.… read more here.
Keywords: cell; brain tumors; brain; vitro assays ... See more keywords