Highly Efficient and Stable Strain-Release Radioiodination for Thiol Chemoselective Bioconjugation.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00790
Abstract: We report a novel thiol selective radioiodination method based on strain-release reaction. A new heterobifunctional radioiodination agent which has very good thiol selectivity and excellent stability with high radiolabeling yield was synthesized, characterized, and applied… read more here.
Keywords: thiol; highly efficient; strain release; radioiodination ... See more keywords
Radioiodination of Modified Porous Silica Nanoparticles as a Potential Candidate of Iodine-131 Drugs Vehicle
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06492
Abstract: There are challenges related to cancer treatment, namely, targeting and biocompatibility associated with a drug vehicle. This research aims to prepare a theranostic cancer vehicle based on porous silica nanoparticles (PSN) with controllable nanoparticle size,… read more here.
Keywords: silica nanoparticles; radioiodination; iodine 131; vehicle ... See more keywords
Site-Specific Radioiodination of Oligonucleotides with a Phenolic Element in a Programmable Approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196257
Abstract: Radioiodination of oligonucleotides provides an extra modality for nucleic acid-based theranostics with potential applications. Herein, we report the design and synthesis of a phosphoramidite embedded with a phenolic moiety and demonstrate that oligonucleotides can be… read more here.
Keywords: radioiodination oligonucleotides; radioiodination; specific radioiodination; site specific ... See more keywords