High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain
Sign Up to like & getrecommendations! Published in 2019 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2018.10.011
Abstract: &NA; PET imaging of amyloid‐beta (A&bgr;) deposits in brain has become an important aid in Alzheimer's disease diagnosis, and an inclusion criterion for patient enrolment into clinical trials of new anti‐A&bgr; treatments. Available PET radioligands… read more here.
Keywords: radioligand; antibody based; 3d6 8d3; bgr ... See more keywords
Structure-Based Design, Optimization, and Development of [18F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00256
Abstract: The cannabinoid receptor type 2 (CB2R) is an attractive target for the diagnosis and therapy of neurodegenerative diseases and cancer. In this study, we aimed at the development of a novel 18F-labeled radioligand starting from… read more here.
Keywords: pet; cannabinoid receptor; 18f lu13; radioligand ... See more keywords
Preclinical Investigations to Explore the Difference between the Diastereomers [177Lu]Lu-SibuDAB and [177Lu]Lu-RibuDAB toward Prostate Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00994
Abstract: [177Lu]Lu-Ibu-DAB-PSMA, a radioligand modified with ibuprofen as the albumin binder, showed higher accumulation in PSMA-positive tumors of mice than the clinically used [177Lu]Lu-PSMA-617 but lower retention in non-targeted tissues than previously developed albumin-binding PSMA radioligands.… read more here.
Keywords: radioligand; 177lu sibudab; 177lu ribudab; psma ... See more keywords
In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00802
Abstract: Microglia play a role in several central nervous system (CNS) diseases and are a highly sought target for positron emission tomography (PET) imaging and therapeutic intervention. 5-Cyano-N-(4-(4-[11C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide ([11C]CPPC) is a radiopharmaceutical designed to selectively target… read more here.
Keywords: radioligand; evaluation cppc; tool; csf ... See more keywords
Selective A3 Adenosine Receptor Antagonist Radioligand for Human and Rodent Species.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00685
Abstract: The A3 adenosine receptor (A3AR) is a target for pain, ischemia, and inflammatory disease therapy. Among the ligand tools available are selective agonists and antagonists, including radioligands, but most high-affinity non-nucleoside antagonists are limited in… read more here.
Keywords: receptor antagonist; radioligand; adenosine receptor; receptor ... See more keywords
Investigating PSMA-Targeted Radioligand Therapy Efficacy as a Function of Cellular PSMA Levels and Intratumoral PSMA Heterogeneity
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1485
Abstract: Purpose: Prostate-specific membrane antigen (PSMA) targeting radioligands deliver radiation to PSMA-expressing cells. However, the relationship between PSMA levels and intralesion heterogeneity of PSMA expression, and cytotoxic radiation by radioligand therapy (RLT) is unknown. Here we… read more here.
Keywords: radioligand; psma levels; efficacy; psma ... See more keywords
Commercial and business aspects of alpha radioligand therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1070497
Abstract: Radioligand therapy (RLT) is gaining traction as a safe and effective targeted approach for the treatment of many cancer types, reflected by a substantial and growing commercial market (valued at $7.78 billion in 2021, with… read more here.
Keywords: radioligand therapeutics; business aspects; commercial business; radioligand ... See more keywords
Factors Influencing the Therapeutic Efficacy of the PSMA Targeting Radioligand 212Pb-NG001
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14112784
Abstract: Simple Summary Prostate-specific membrane antigen (PSMA) is a protein overexpressed in metastatic castration-resistant prostate cancer and a promising target for targeted radionuclide therapy. PSMA-targeted alpha therapy is of growing interest due to the high-emission energy… read more here.
Keywords: 212pb ng001; psma targeting; radioligand; psma ... See more keywords
Application of Cleavable Linkers to Improve Therapeutic Index of Radioligand Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154959
Abstract: Radioligand therapy (RLT) is an emergent drug class for cancer treatment. The dose administered to cancer patients is constrained by the radiation exposure to normal tissues to maintain an appropriate therapeutic index. When a radiopharmaceutical… read more here.
Keywords: cleavable linkers; application cleavable; therapeutic index; linkers improve ... See more keywords
A High-Affinity 64Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15091109
Abstract: Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate. This study aimed to develop a… read more here.
Keywords: imaging hepsin; prostate cancer; hepsin; radioligand ... See more keywords
Safety of High-Dose Botulinum Toxin Injections for Parotid and Submandibular Gland Radioprotection
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14010064
Abstract: Botulinum Toxin injections into salivary glands (SG) up to a total dose of 100 units IncobotulinumtoxinA (IncoA) represent the treatment of choice for sialorrhea. However, BTX might also protect SG against sialotoxic radioligand cancer therapies.… read more here.
Keywords: gland; submandibular gland; botulinum toxin; toxin injections ... See more keywords