Association of Upfront Peptide Receptor Radionuclide Therapy With Progression-Free Survival Among Patients With Enteropancreatic Neuroendocrine Tumors
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.0290
Abstract: This cohort study assesses the association of upfront peptide receptor radionuclide therapy (PRRT) vs upfront chemotherapy or targeted therapy with progression-free survival among patients in Italy with enteropancreatic neuroendocrine tumors who experienced disease progression after… read more here.
Keywords: receptor radionuclide; association upfront; progression; peptide receptor ... See more keywords
Lutetium 177 PSMA radionuclide therapy for men with prostate cancer: a review of the current literature and discussion of practical aspects of therapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Radiation Sciences"
DOI: 10.1002/jmrs.227
Abstract: Prostate‐specific membrane antigen (PSMA) is a receptor on the surface of prostate cancer cells that is revolutionising the way we image and treat men with prostate cancer. New small molecule peptides with high‐binding affinity for… read more here.
Keywords: psma; prostate cancer; men prostate; cancer ... See more keywords
Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment
Sign Up to like & getrecommendations! Published in 2018 at "Medical Physics"
DOI: 10.1002/mp.13165
Abstract: PURPOSE Dosimetry for melanoma-targeted radionuclide therapy (TRT) with [131 I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de… read more here.
Keywords: melanoma; icf01012; targeted radionuclide; dosimetry ... See more keywords
Voxel-based dosimetry is superior to mean-absorbed dose approach for establishing dose-effect relationship in targeted radionuclide therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Medical physics"
DOI: 10.1002/mp.13851
Abstract: It is becoming evident that patient-individualized dosimetry in targeted radionuclide therapy (TRT) is a must and not a luxury in the era of precision medicine. It's often argued that patient-specific absorbed dose assessment should be… read more here.
Keywords: radionuclide therapy; relationship; dosimetry; absorbed dose ... See more keywords
Personalized 177Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: initial results from the P-PRRT trial
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4209-7
Abstract: PurposePeptide receptor radionuclide therapy (PRRT) is mostly administered using a fixed injected activity (IA) per cycle. This empiric regime results in highly variable absorbed doses to the critical organs and undertreatment of the majority of… read more here.
Keywords: initial results; response; 177lu octreotate; prrt trial ... See more keywords
A theranostic approach of [68Ga]Ga-DOTA.SA.FAPi PET/CT-guided [177Lu]Lu-DOTA.SA.FAPi radionuclide therapy in an end-stage breast cancer patient: new frontier in targeted radionuclide therapy
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04990-w
Abstract: A 31-year-young female was diagnosed with breast cancer in September 2019. The histopathology revealed atypical cells arranged cords and tubules in the fibrotic stroma suggestive of invasive ductal carcinoma of the breast and the immunohistochemistry… read more here.
Keywords: pet; dota fapi; fig; radionuclide therapy ... See more keywords
Extensive preclinical evaluation of lutetium-177-labeled PSMA-specific tracers for prostate cancer radionuclide therapy
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05057-6
Abstract: Various radiolabeled prostate-specific membrane antigen (PSMA)–targeting tracers are clinically applied for prostate cancer (PCa) imaging and targeted radionuclide therapy. The PSMA binding affinities, biodistribution, and DNA-damaging capacities of these radiotracers have not yet been compared… read more here.
Keywords: psma 617; 177lu psma; prostate cancer; evaluation ... See more keywords
Functionalized TiO2 nanoparticles labelled with 225Ac for targeted alpha radionuclide therapy
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DOI: 10.1007/s11051-018-4181-y
Abstract: The 225Ac radioisotope exhibits very attractive nuclear properties for application in radionuclide therapy. Unfortunately, the major challenge for radioconjugates labelled with 225Ac is that traditional chelating moieties are unable to sequester the radioactive daughters in… read more here.
Keywords: nanoparticles labelled; functionalized tio2; radionuclide therapy; tio2 nanoparticles ... See more keywords
Strategies Towards Improving Clinical Outcomes of Peptide Receptor Radionuclide Therapy
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DOI: 10.1007/s11912-021-01037-7
Abstract: Peptide receptor radionuclide therapy (PRRT) with [177Lu-DOTA0,Tyr3] octreotate is an effective and safe second- or third-line treatment option for patients with low-grade advanced gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN). In this review, we will focus on… read more here.
Keywords: radionuclide therapy; prrt; receptor radionuclide; receptor ... See more keywords
Peptide receptor radionuclide therapy after NETTER-1 clinical trial: what should not be left behind
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Translational Imaging"
DOI: 10.1007/s40336-019-00327-2
Abstract: Peptide receptor radionuclide therapy (PRRT) is an established therapy that takes advantage of the over-expression of somatostatin receptors (SSTRs) on neuroendocrine tumor cell surface, to vehicle radioactivity on cancer tissues. Approximately 80% of neuroendocrine tumors… read more here.
Keywords: radionuclide; receptor radionuclide; therapy; radionuclide therapy ... See more keywords
[I183] Guidelines for medical physics staffing requirements in diagnistic imaging and radionuclide therapy
Sign Up to like & getrecommendations! Published in 2018 at "Physica Medica"
DOI: 10.1016/j.ejmp.2018.06.255
Abstract: Purpose Over the last decades, the rapid technological development of diagnostic and interventional radiology and nuclear medicine has made them major tools of modern medicine. However, at the same time, the involved risks, the growing… read more here.
Keywords: medicine; medical physicists; medical physics; physics ... See more keywords