Modeling Gold Nanoparticle Radiosensitization using a Clustering Algorithm to Quantify DNA Double-Strand Breaks with Mixed-Physics Monte Carlo Simulation.
Sign Up to like & getrecommendations! Published in 2019 at "Medical physics"
DOI: 10.1002/mp.13813
Abstract: PURPOSE The radiosensitization properties of gold nanoparticles (GNPs) are investigated using a simple Geant4 cell model considering a realistic cell geometry and a clustering algorithm to characterize the number of DNA double strand breaks (DSBs).… read more here.
Keywords: radiosensitization; dna; physics; enhancement factor ... See more keywords
Radiosensitization by Au-nanofilm at micrometer level using confocal Raman spectroscopy.
Sign Up to like & getrecommendations! Published in 2020 at "Medical physics"
DOI: 10.1002/mp.14570
Abstract: PURPOSE To measure the radiosensitization by an Au-nanofilm (GNF) at a micrometer level on a radiochromic film (RCF) using confocal Raman spectroscopy (CRS). METHODS Unlaminated radiochromic films were irradiated by 200 kVp X-ray from 0.3… read more here.
Keywords: rcf; radiosensitization; spectroscopy; confocal raman ... See more keywords
Acid-Responsive Aggregated Gold Nanoparticles for Radiosensitization and Synergistic Chemoradiotherapy in the Treatment of Esophageal Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200115
Abstract: Radiotherapy and chemotherapy are limited by insufficient therapeutic efficacy of low-dose radiation and nonspecific drug biodistribution. Herein, an acid-responsive aggregated nanosystem (AuNPs-D-P-DA) loaded with doxorubicin (DOX) is designed for radiosensitization and synergistic chemoradiotherapy. In response… read more here.
Keywords: radiosensitization; responsive aggregated; aunps; acid responsive ... See more keywords
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204238
Abstract: Over half of cancer patients are subjected to radiotherapy, but owing to the deficient amount of reactive oxygen radicals (ROS) and DNA double-strand breaks (DSBs), a fair number of them suffer from radiotherapy resistance and… read more here.
Keywords: radiosensitization; coordination supermolecule; infinite coordination; peptide infinite ... See more keywords
The dependence of radiosensitization efficiency on mitochondrial targeting with NaGdF4:Yb,Er nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.06.041
Abstract: Radiosensitization is highly desired to reduce side-effect of the harsh dose of radiation therapy (RT), for which nanoparticles with high atomic number elements provide a promising tool. However, insufficient knowledge on utilizing the interaction between… read more here.
Keywords: efficiency mitochondrial; radiosensitization; mitochondrial targeting; dependence radiosensitization ... See more keywords
In Situ Formed Z-Scheme Graphdiyne Heterojunction Realizes NIR-Photocatalytic Oxygen Evolution and Selective Radiosensitization for Hypoxic Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c09169
Abstract: Photon radiotherapy is a common tool in the armory against tumors, but it is limited by hypoxia-related radioresistance of tumors and radiotoxicity to normal tissues. Here, we constructed a spatiotemporally controlled synergistic therapy platform based… read more here.
Keywords: radiosensitization; situ formed; heterojunction; cuo gdy ... See more keywords
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.7b03037
Abstract: Radioresistance is one of the undesirable impediments in hypoxic tumors, which sharply diminishes the therapeutic effectiveness of radiotherapy and eventually results in the failure of their treatments. An attractive strategy for attenuating radioresistance is developing… read more here.
Keywords: polyoxometalate based; radiosensitization; response; attenuating radioresistance ... See more keywords
Interplay between the gold nanoparticle sub-cellular localization, size, and the photon energy for radiosensitization
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13736-y
Abstract: There are large variations in the reported efficiency of gold nanoparticle (GNP) radiosensitization. We have previously reported on a predictive model, which accounts for the detailed Auger and photoelectron tracks to calculate the cell survival… read more here.
Keywords: photon; radiosensitization; energy; size ... See more keywords
CX-5461 induces radiosensitization through modification of the DNA damage response and not inhibition of RNA polymerase I
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-07928-4
Abstract: Increased ribosome biogenesis is a distinguishing feature of cancer cells, and small molecule inhibitors of ribosome biogenesis are currently in clinical trials as single agent therapy. It has been previously shown that inhibiting ribosome biogenesis… read more here.
Keywords: dna; inhibition; rna polymerase; radiation ... See more keywords
Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2020.1730014
Abstract: Abstract Purpose Head and neck cancers (HNSCC) are routinely treated with radiotherapy; however, normal tissue toxicity remains a concern. Therefore, it is important to validate treatment modalities combining molecularly targeted agents with radiotherapy to improve… read more here.
Keywords: radiosensitization; hpv; cell cycle; hpv cells ... See more keywords
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1101/2022.09.27.509658
Abstract: DNA polymerase theta (Polθ) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but is frequently overexpressed in cancer cells and, therefore, represents an ideal… read more here.
Keywords: radiosensitization; small molecule; pol inhibition; pol inhibitors ... See more keywords