Copper-Mediated Radiosynthesis of [18F]Rucaparib.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02770
Abstract: The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation. The most successful… read more here.
Keywords: copper mediated; mediated radiosynthesis; rucaparib; 18f rucaparib ... See more keywords
Novel late-stage radiosynthesis of 5-[18F]-trifluoromethyl-1,2,4-oxadiazole (TFMO) containing molecules for PET imaging
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DOI: 10.1038/s41598-021-90069-x
Abstract: Small molecules that contain the (TFMO) moiety were reported to specifically inhibit the class-IIa histone deacetylases (HDACs), an important target in cancer and the disorders of the central nervous system (CNS). However, radiolabeling methods to… read more here.
Keywords: late stage; tfmo; tfmo containing; novel late ... See more keywords