Association of the Placement of a Perirectal Hydrogel Spacer With the Clinical Outcomes of Men Receiving Radiotherapy for Prostate Cancer: A Systematic Review and Meta-analysis.
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DOI: 10.1001/jamanetworkopen.2020.8221
Abstract: Importance Perirectal spacers are intended to lower the risk of rectal toxic effects associated with prostate radiotherapy. A quantitative synthesis of typical clinical results with specific perirectal spacers is limited. Objective To evaluate the association… read more here.
Keywords: prostate; spacer; radiotherapy; group ... See more keywords
Response-Adapted Treatment Following Radiotherapy in Patients With Resectable Locally Advanced Hypopharyngeal Carcinoma
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DOI: 10.1001/jamanetworkopen.2022.0165
Abstract: Key Points Question Is a response-adapted strategy based on early tumor response to radiotherapy associated with improved survival with a functional larynx in patients with resectable locally advanced hypopharyngeal carcinoma? Findings In this cohort study… read more here.
Keywords: locally advanced; radiotherapy; response adapted; patients resectable ... See more keywords
Assessment of Second Primary Cancer Risk Among Men Receiving Primary Radiotherapy vs Surgery for the Treatment of Prostate Cancer
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DOI: 10.1001/jamanetworkopen.2022.23025
Abstract: Key Points Question Do patients with prostate cancer in the modern era have a higher incidence and risk of developing a second primary cancer after radiotherapy compared with nonradiotherapy treatments? Findings In this cohort study… read more here.
Keywords: prostate cancer; second primary; primary cancer; radiotherapy ... See more keywords
Association of Regional Intensity of Ductal Carcinoma In Situ Treatment With Likelihood of Breast Preservation
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DOI: 10.1001/jamaoncol.2016.2164
Abstract: Importance Large regional variation exists in the use of radiotherapy after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). Although patients who do not receive initial radiotherapy for DCIS are candidates for subsequent BCS… read more here.
Keywords: use; seer; breast; dcis ... See more keywords
Effect of Standard Radiotherapy With Cisplatin vs Accelerated Radiotherapy With Panitumumab in Locoregionally Advanced Squamous Cell Head and Neck Carcinoma: A Randomized Clinical Trial
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DOI: 10.1001/jamaoncol.2016.4510
Abstract: Importance The Canadian Cancer Trials Group study HN.6 is the largest randomized clinical trial to date comparing the concurrent administration of anti–epidermal growth factor receptor (EGFR) monoclonal antibodies with radiotherapy (RT) to standard chemoradiotherapy in… read more here.
Keywords: clinical trial; pfs; trial; fractionation ... See more keywords
Demonstrating Noninferiority of Accelerated Radiotherapy With Panitumumab vs Standard Radiotherapy With Cisplatin in Locoregionally Advanced Squamous Cell Head and Neck Carcinoma.
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DOI: 10.1001/jamaoncol.2017.0737
Abstract: Demonstrating Noninferiority of Accelerated Radiotherapy With Panitumumab vs Standard Radiotherapy With Cisplatin in Locoregionally Advanced Squamous Cell Head and Neck Carcinoma To the Editor Siu and colleagues1 conducted the largest clinical trial to date to… read more here.
Keywords: plus panitumumab; radiotherapy; afx plus; plus cisplatin ... See more keywords
Association of HSD3B1 Genotype With Response to Androgen-Deprivation Therapy for Biochemical Recurrence After Radiotherapy for Localized Prostate Cancer
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DOI: 10.1001/jamaoncol.2017.3164
Abstract: Importance The variant HSD3B1 (1245C) allele enhances dihydrotestosterone synthesis and predicts resistance to androgen-deprivation therapy (ADT) for biochemically recurrent prostate cancer after prostatectomy and for metastatic disease. Whether this is true after radiotherapy is unknown.… read more here.
Keywords: radiotherapy; biochemical recurrence; prostate cancer; variant alleles ... See more keywords
Characteristics of Radiotherapy Trials Compared With Other Oncological Clinical Trials in the Past 10 Years
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DOI: 10.1001/jamaoncol.2018.0887
Abstract: Importance Modern precision radiotherapy is an innovative and effective treatment of cancer, yet it is unclear how radiotherapy trials are affected by expanding targeted and immune therapies and declining National Institutes of Health funding. Objective… read more here.
Keywords: oncological trials; radiotherapy; trials compared; radiotherapy trials ... See more keywords
Assessment of Use, Specificity, and Readability of Written Clinical Informed Consent Forms for Patients With Cancer Undergoing Radiotherapy.
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DOI: 10.1001/jamaoncol.2019.0260
Abstract: Importance Appropriate informed consent processes are crucial to preservation of patient autonomy and shared decision making. Although half of patients with cancer receive radiotherapy, it is unknown whether current consent practices are comprehensible for patients.… read more here.
Keywords: readability; radiotherapy; consent; consent forms ... See more keywords
Assessment of Safety and Efficacy of Combined Trabectedin and Low-Dose Radiotherapy for Patients With Metastatic Soft-Tissue Sarcomas: A Nonrandomized Phase 1/2 Clinical Trial.
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DOI: 10.1001/jamaoncol.2019.6584
Abstract: Importance Active therapeutic combinations, such as trabectedin and radiotherapy, offer potentially higher dimensional response in second-line treatment of advanced soft-tissue sarcomas. Dimensional response can be relevant both for symptom relief and for survival. Objective To… read more here.
Keywords: phase; metastatic soft; soft tissue; radiotherapy ... See more keywords
Interplay Between Duration of Androgen Deprivation Therapy and External Beam Radiotherapy With or Without a Brachytherapy Boost for Optimal Treatment of High-risk Prostate Cancer
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DOI: 10.1001/jamaoncol.2021.6871
Abstract: Key Points Question What is the optimal minimum duration of androgen deprivation therapy (ADT) when treating high-risk prostate cancer with high-dose radiotherapy? Findings This patient-level cohort study of 3 cohorts found a significant interaction between… read more here.
Keywords: beam radiotherapy; radiotherapy; brachytherapy boost; external beam ... See more keywords