Enhanced radiotherapy efficacy and induced anti-tumor immunity in HCC by improving hypoxia microenvironment using oxygen microcapsules
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DOI: 10.1016/j.cej.2021.130109
Abstract: Abstract Hypoxia represents a tremendous barrier for effective radiotherapy in hepatocellular carcinoma (HCC). Treatment strategies for improving hypoxia are of great significance to enhance radiotherapy efficacy. Here, we design polydopamine-nanoparticle-stabilized oxygen microcapsules by interfacial polymerization,… read more here.
Keywords: radiotherapy efficacy; improving hypoxia; oxygen microcapsules; tumor ... See more keywords
Impact of radiotherapy on efficacy of anti-programmed death 1 (PD-1) antibodies in metastatic NSCLC
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DOI: 10.1093/annonc/mdz260.039
Abstract: Abstract Background The impact of radiotherapy (RT) on the efficacy and toxicity of immune checkpoint inhibitors in patients (pts) with metastatic non-small cell-lung cancer (NSCLC) is unclear. Methods We retrospectively identified pts with metastatic NSCLC… read more here.
Keywords: radiotherapy efficacy; treatment; radiotherapy; metastatic nsclc ... See more keywords
Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α
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DOI: 10.2147/ott.s187615
Abstract: Purpose Pancreatic cancer is characterized by a hypoxic microenvironment and resistance to most currently available treatment modalities. Prolyl hydroxylase domain 3 (PHD3) is a rate-limiting enzyme that regulates the degradation of hypoxia-inducible factors (HIFs) and… read more here.
Keywords: radiotherapy efficacy; hypoxia; pancreatic cancer; efficacy pancreatic ... See more keywords
The Research Progress of PD-1/PD-L1 Inhibitors Enhancing Radiotherapy Efficacy
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DOI: 10.3389/fonc.2021.799957
Abstract: Approximately 60%–70% of patients with malignant tumours require radiotherapy. The clinical application of immune checkpoint inhibitors (ICIs), such as anti-PD-1/PD-L1, has revolutionized cancer treatment and greatly improved the outcome of a variety of cancers by… read more here.
Keywords: effect radiotherapy; research progress; radiotherapy efficacy; radiotherapy ... See more keywords