In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04589-w
Abstract: Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher… read more here.
Keywords: 18f avt; avt 011; pet imaging; multidrug resistance ... See more keywords
Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-05149-3
Abstract: Purpose Synaptic abnormalities are associated with many brain disorders. Recently, we developed a novel synaptic vesicle glycoprotein 2A (SV2A) radiotracer [ 18 F]SynVesT-1 and demonstrated its excellent imaging and binding properties in nonhuman primates. The… read more here.
Keywords: reproducibility; test retest; test; synaptic vesicle ... See more keywords
First in Human Evaluation and Dosimetry Calculations for Peptide 124I-p5+14—a Novel Radiotracer for the Detection of Systemic Amyloidosis Using PET/CT Imaging
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-021-01681-2
Abstract: Accurate diagnosis of amyloidosis remains a significant clinical challenge and unmet need for patients. The amyloid-reactive peptide p5+14 radiolabeled with iodine-124 has been developed for the detection of amyloid by PET/CT imaging. In a first-in-human… read more here.
Keywords: detection; pet imaging; amyloidosis; dosimetry ... See more keywords
Radiotracer techniques (18F) and modeling of fluoride sorption on alumina
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.04.001
Abstract: Abstract Chemical equilibria on the removal of excess fluoride from water by a classic solid alumina are presented. The fluoride concentrations used are representatives of those reported in borewell water at North region of Zacatecas… read more here.
Keywords: alumina; surface; fluoride sorption; fluoride removal ... See more keywords
Photoradiosynthesis of 68Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00342
Abstract: In an alternative approach for radiotracer design, a photoactivatable HBED-CC-PEG3-ArN3 chelate was synthesized and photoconjugated to the anti-c-MET antibody MetMAb (onartuzumab). Photoconjugation gave the functionalized protein HBED-CC-azepin-MetMAb with a photochemical conversion of 18.5 ± 0.5%… read more here.
Keywords: photoradiosynthesis 68ga; metmab; immuno pet; hbed azepin ... See more keywords
Radiosynthesis and biological evaluation of [18F]Triacoxib: A new radiotracer for PET imaging of COX-2.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00986
Abstract: Inducible isozyme cyclooxygenase-2 (COX-2) is upregulated under acute and chronic inflammatory conditions, including cancer, wherein it promotes angiogenesis, tissue invasion, and resistance to apoptosis. Due to its high expression in various cancers, COX-2 has become… read more here.
Keywords: radiotracer; pet imaging; chemistry; 18f triacoxib ... See more keywords
Construction and Preclinical Evaluation of a 124/131I-labeled radiotracer for the Detection of Mesothelin-Overexpressing Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b01281
Abstract: Mesothelin is a molecular biomarker of many types of solid cancers, which may represent a highly promising new target in the development of cancer-targeted diagnostic agents. A human anti-mesothelin antibody with a low molecular weight,… read more here.
Keywords: labeled radiotracer; 124 131i; mesothelin; 131i labeled ... See more keywords
Synthesis and Evaluation of a New 18F-Labeled Radiotracer for Studying the GABAB Receptor in the Mouse Brain.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00038
Abstract: New GABAB agonists, fluoropyridyl ether analogues of baclofen, have been synthesized as potential PET radiotracers. The compound with highest inhibition binding affinity as well as greatest agonist response, ( R)-4-amino-3-(4-chloro-3-((2-fluoropyridin-4-yl)methoxy)phenyl)butanoic acid (1b), was radiolabeled with… read more here.
Keywords: mouse brain; evaluation new; synthesis evaluation; brain ... See more keywords
PET Cell Tracking Using 18F-FLT is Not Limited by Local Reuptake of Free Radiotracer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44233
Abstract: Assessing the retention of cell therapies following implantation is vital and often achieved by labelling cells with 2′-[18F]-fluoro-2′-deoxy-D-glucose (18F-FDG). However, this approach is limited by local retention of cell-effluxed radiotracer. Here, in a preclinical model… read more here.
Keywords: cell tracking; 18f flt; 18f fdg; cell ... See more keywords
Comparative Analysis of Postoperative Complications of Sentinel Node Identification Using the SentiMag® Method and the Use of a Radiotracer in Patients with Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology"
DOI: 10.3390/curroncol29050235
Abstract: (1) Background: The purpose of the study was a retrospective, comparative assessment of complications of the surgical sentinel node biopsy (SNB) procedure in breast cancer using the radiotracer method and the SentiMag® method on groups… read more here.
Keywords: radiotracer; sentinel node; breast cancer; method ... See more keywords