SH3 domain-binding kinase 1 promotes proliferation and inhibits apoptosis of cervical cancer via activating the Wnt/β-catenin and Raf/ERK1/2 signaling pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23552
Abstract: SH3 domain-binding kinase 1 (SBK1), is a member of the serine/threonine protein kinases family, and was confirmed to be upregulated in cervical cancer in our previous study. Nonetheless, the role of SBK1 in regulating cancer… read more here.
Keywords: cervical cancer; wnt catenin; raf; cancer ... See more keywords
Effect of soil moisture on root-associated fungal communities of Erica dominans in Drakensberg mountains in South Africa
Sign Up to like & getrecommendations! Published in 2017 at "Mycorrhiza"
DOI: 10.1007/s00572-017-0760-5
Abstract: Ericoid mycorrhiza represents a key adaptation of the Ericaceae plants to facilitate their establishment in harsh conditions. The Ericaceae are a large family of flowering plants, with global distribution. However, our current knowledge about the… read more here.
Keywords: communities erica; erica dominans; raf; drakensberg mountains ... See more keywords
A novel amorphous solid dispersion based on drug-polymer complexation.
Sign Up to like & getrecommendations! Published in 2020 at "Drug delivery and translational research"
DOI: 10.1007/s13346-020-00869-3
Abstract: Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP… read more here.
Keywords: raf; drug polymer; complexation; drug ... See more keywords
Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103349
Abstract: In the present work, a novel series of B-RAF kinase inhibitors having imidazo[2,1-b]oxazole scaffold was designed and synthesized based on the structures of the well-known B-RAF inhibitors. The twenty two final compounds were tested over… read more here.
Keywords: kinase inhibitors; imidazo oxazole; raf; raf kinase ... See more keywords
C-RAF function at the genome-wide transcriptome level: A systematic view.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.02.034
Abstract: C-RAF was the first member of the RAF kinase family to be discovered. Since its discovery, C-RAF has been found to regulate many fundamental cell processes, such as cell proliferation, cell death, and metabolism. However,… read more here.
Keywords: view raf; raf function; function genome; raf ... See more keywords
Dominant-negative antagonists of the Ras-ERK pathway: DA-Raf and its related proteins generated by alternative splicing of Raf.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111775
Abstract: The Ras-ERK pathway regulates a variety of cellular and physiological responses, including cell proliferation, differentiation, morphogenesis during animal development, and homeostasis in adults. Deregulated activation of this pathway leads to cellular transformation and tumorigenesis as… read more here.
Keywords: dominant negative; raf; ras erk; erk pathway ... See more keywords
Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00025
Abstract: respectively). As shown in Table 1, the correct RAF1B1 and RAF1B3 values for lot OJE were 3.65 and 0.627, respectively, which provided the CLuptake,1B1+1B3,RAF values in the amended Table 3 shown herein. By using the… read more here.
Keywords: clearance mediated; lot oje; raf; raf based ... See more keywords
A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47354-7
Abstract: The rapidly accelerated fibrosarcoma (Raf) kinase is canonically activated by growth factors that regulate multiple cellular processes. In this kinase cascade Raf activation ultimately results in extracellular regulated kinase 1/2 (Erk1/2) activation, which requires Ras… read more here.
Keywords: raf; raf kinase; activation; retinoic acid ... See more keywords
Effects of CNTs on thermal transitions, thermal diffusivity and electrical conductivity in nanocomposites: comparison between an amorphous and a semicrystalline polymer matrix.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c8sm02478b
Abstract: Two series of polymer nanocomposites (PNCs) based on amorphous styrene-butadiene rubber (SBR) and semicrystalline linear low-density polyethylene (PE) matrices were filled with 2-15 wt% carbon nanotubes (CNT) and were studied by employing calorimetry, dielectric spectroscopy… read more here.
Keywords: electrical conductivity; thermal diffusivity; polymer; raf ... See more keywords
Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1805950115
Abstract: Significance Here, we report that the long noncoding RNA (lncRNA) ovarian adenocarcinoma-amplified lncRNA (OVAAL) is a mediator of cancer cell resistance, counteracting the effects of apoptosis-inducing agents acting through both the extrinsic and intrinsic pathways.… read more here.
Keywords: mek erk; raf; cancer; cell ... See more keywords
Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113491119
Abstract: Significance RAF inhibitors unexpectedly induce ERK activation in normal and oncogenic RAS tumor cells, making them unsuitable for treating RAS-driven cancers. The precise mechanism of this paradox is not fully understood but is believed to… read more here.
Keywords: paradoxical erk; erk activation; raf; raf inhibitors ... See more keywords